Natural Product Biosynthesis by Microorganisms and Plants Part B

Edited by

  • David Hopwood, John Innes Centre and AFRC Institute of Plant Science Research, Norwich, UK

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The second of 3 volumes covering Natural product biosynthesis by microorganisms and plants.
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Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists


Book information

  • Published: October 2012
  • ISBN: 978-0-12-394291-3

Table of Contents

  1. In vivo production of thiopeptide variants
    Feifei Zhang and Wendy L. Kelly
  2. Microviridin biosynthesis
    Thomas K. Hemscheidt
  3. Cyclotide isolation and characterization
    David J. Craik, Sonia Troeira Henriques, Joshua S. Mylne and Conan K. Wang
  4. Ribosomally-encoded cyclic peptide toxins from mushrooms
    Jonathan Walton, Hong Luo, and Heather Hallen-Adams
  5. The Pictet-Spengler mechanism involved in the biosynthesis of tetrahydroisoquinoline antitumor antibiotics: novel function for a non-ribosomal peptide synthetase
    Kento Koketsu, Atsushi Minami, Kenji Watanabe, Hiroki Oguri and Hideaki Oikawa
  6. Discovery and biosynthesis of phosphonate and phosphinate natural products
    Spencer C. Peck, Jiangtao Gao, and Wilfred A. van der Donk
  7. RlmN and AtsB as models for the overproduction and characterization of radical SAM proteins
    Nicholas D. Lanz, Tyler, L. Grove, Camelia Gogonea, Carsten Krebs, and Squire J. Booker
  8. Fe(II)-dependent, uridine-5’-monophosphate α-ketoglutarate dioxygenases in the synthesis of 5’-modified nucleosides
    Zhaoyong Yang, Jason Unrine, Koichi Nonaka, and Steven G. Van Lanen
  9. Heme-dependent Tailoring Enzymes in Natural Product Biosynthesis: Spectroscopic Characterisation of the L-tryptophan-nitrating Cytochrome P450 TxtE
    S. M. Barry and Greg Challis
  10. Oxidative Tailoring Reactions Catalysed by Non-heme Iron-dependent Enzymes: Streptorubin B Biosynthesis as an Example
    Paulina K. Sydor and Greg Challis
  11. The rare fluorinated natural products and biotechnological prospects for fluorine enzymology
    K. K. Jason Chan and David O’Hagan
  12. Enzymatic chlorination and bromination
    Karl-Heinz van Pée
  13. Prenyltransferases of the dimethylallyltryptophan synthase superfamily
    Xia Yu and Shu-Ming Li
  14. Serine carboxypeptidase-like acyltransferases from plants
    Sam T. Mugford and Carsten Milkowski
  15. 4-Methylideneimidazole-5-one-containing aminomutases in enediyne biosynthesis
    Jeremy R. Lohman and Ben Shen
  16. Tailoring enzymes acting on carrier protein-tethered substrates in natural product biosynthesis
    Shuangjun Lin, Tingting Huang, and Ben Shen
  17. High-throughput colorimetric assays for nucleotide sugar formation and glycosyl transfer
    Richard W. Gantt and Jon S. Thorson