Natural Product Biosynthesis by Microorganisms and Plants Part B

Edited by

David Hopwood, John Innes Centre and AFRC Institute of Plant Science Research, Norwich, UK

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The second of 3 volumes covering Natural product biosynthesis by microorganisms and plants.

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Hardbound, 462 Pages

Published: October 2012

Imprint: Academic Press

ISBN: 978-0-12-394291-3

1. In vivo production of thiopeptide variants
  Feifei Zhang and Wendy L. Kelly
2. Microviridin biosynthesis
  Thomas K. Hemscheidt
3. Cyclotide isolation and characterization
  David J. Craik, Sonia Troeira Henriques, Joshua S. Mylne and Conan K. Wang
4. Ribosomally-encoded cyclic peptide toxins from mushrooms
  Jonathan Walton, Hong Luo, and Heather Hallen-Adams
5. The Pictet-Spengler mechanism involved in the biosynthesis of tetrahydroisoquinoline antitumor antibiotics: novel function for a non-ribosomal peptide synthetase
  Kento Koketsu, Atsushi Minami, Kenji Watanabe, Hiroki Oguri and Hideaki Oikawa
6. Discovery and biosynthesis of phosphonate and phosphinate natural products
  Spencer C. Peck, Jiangtao Gao, and Wilfred A. van der Donk
7. RlmN and AtsB as models for the overproduction and characterization of radical SAM proteins
  Nicholas D. Lanz, Tyler, L. Grove, Camelia Gogonea, Carsten Krebs, and Squire J. Booker
8. Fe(II)-dependent, uridine-5-monophosphate a-ketoglutarate dioxygenases in the synthesis of 5-modified nucleosides
  Zhaoyong Yang, Jason Unrine, Koichi Nonaka, and Steven G. Van Lanen
9. Heme-dependent Tailoring Enzymes in Natural Product Biosynthesis: Spectroscopic Characterisation of the L-tryptophan-nitrating Cytochrome P450 TxtE
  S. M. Barry and Greg Challis
10. Oxidative Tailoring Reactions Catalysed by Non-heme Iron-dependent Enzymes: Streptorubin B Biosynthesis as an Example
  Paulina K. Sydor and Greg Challis
11. The rare fluorinated natural products and biotechnological prospects for fluorine enzymology
  K. K. Jason Chan and David OHagan
12. Enzymatic chlorination and bromination
  Karl-Heinz van Pée
13. Prenyltransferases of the dimethylallyltryptophan synthase superfamily
  Xia Yu and Shu-Ming Li
14. Serine carboxypeptidase-like acyltransferases from plants
  Sam T. Mugford and Carsten Milkowski
15. 4-Methylideneimidazole-5-one-containing aminomutases in enediyne biosynthesis
  Jeremy R. Lohman and Ben Shen
16. Tailoring enzymes acting on carrier protein-tethered substrates in natural product biosynthesis
  Shuangjun Lin, Tingting Huang, and Ben Shen
17. High-throughput colorimetric assays for nucleotide sugar formation and glycosyl transfer
  Richard W. Gantt and Jon S. Thorson

Natural Product Biosynthesis by Microorganisms and Plants Part B

Contents