Myelin Biology and Disorders, Two-Volume Set


  • Robert Lazzarini, The Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY, U.S.A.

With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. Myelin Biology and Disorders brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into disease mechanisms. This book represents a unique research reference on myelin biology and will serve as the definitive resource for both the professional clinical and basic scientist.
View full description


Neurologists, neurobiologists, and cell biologists.


Book information

  • Published: December 2003
  • ISBN: 978-0-12-439510-7


"Myelin Biology and Disorders, an extraordinary compilation of knowledge about myelin and myelin diseases, benefits from the intrinsic interest and importance of the topic no less than from the hard work of its contributing authors. ...Myelin Biology and Disorders represents a bravura achievement for all concerned and, now, a standard for the field." --THE NEW ENGLAND JOURNAL OF MEDICINE(October 21, 2004) "...a splendid book, an important addition to any serious clinical neuroscience bookshelf, and of lasting value: it is an outstanding achievement on the part of the Editor and the publisher." --BRAIN, 2005 " medical library or institution with a neuroscience research program can afford to be without a copy of this treatise. Lazzarini and his five section editors are to be applauded for overseeing the production of such a well-illustrated and thorough work on this set of major debilitating diseases. There is also an excellent historical preface that recounts the work of the remarkable set of early researchers whose splendid work in the late 19th and early 20th centuries founded this important field of research." --Lloyd Davidson, Life Sciences Librarian, Head, Access Services and Kaplan Humanities Fellow, Northwestern University Seeley G. Mudd Library for Science and Engineering, E-STREAMS Vol 7 No 11, November 2004) "Under the baton of Robert Lazzarini, five distinguished editors have assembled a comprehensive treatise covering the origin and neurobiology of myelin-forming cells, the assembly of the myelin sheath and its often unforgiving diseases." --Monique Dubois-Dalcq, MD, Department of Neuroscience, The Pasteur Institute, Paris, France "This book comprises comprehensive, thoughtfully edited, uniformly first-rate chapters on myelination. It is the definitive work in the field." --David R. Colman. Ph.D., Director, The Montreal Neurological Institute "The two volumes on Glial Cell and Myelin Functional Biology serve as an impressive platform to showcase the rich literature on oligodendrocytes and Schwann cells in development and disease...The current and comprehensive style will make this book a standard for the field." --Moses V. Chao, Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York City, U.S.A.

Table of Contents

Section I: Diseases of MyelinLeukodystrophies: Overview and ClassificationMultiple Sclerosis: Classification and OverviewGenetic Susceptibility and EpidemiologyCellular Damage and Repair in MSMRI Visualization of MSMultiple Sclerosis (General Clinical and Trials)AdrenoleukodystrophiesKrabbe's DiseaseAlexander's DiseasePelizeaus-Merzbacher DiseaseGuillain Barre SyndromeCharcot-Marie-Tooth DiseaseInfectious Demyelinating DiseasesIschemic White Matter DamageProtein Misfolding as a Disease DeterminantSection II: Animals Models of Human DiseaseExperimental Allergic EncephalomyelitisExperimental Models of Virus Induced DemyelinationModel's of Krabbe's DiseaseModel's of Alexander's DiseaseModel's of Pelizeaus Merzbacher DiseaseModels of Charcot-Marie-Tooth DiseaseSection III: The Myelin Genes and ProductsMyelin Basic Protein GeneProteolipid Protein GeneMyelin Associated Glycoprotein GeneMyelin Oligodendrocyte Glycoprotein GeneCyclic Nucleotide Phosophohydrolase GeneP0 Protein GenePMP 22 GeneThe Claudin 11 GeneThe Neurexin GeneThe Connexin 32 GeneThe Integrin GenesThe Periaxin GeneThe QK1 GeneSection IV: Glial Cell DevelopmentInvertebrate GliaNeural Cell Specification During DevelopmentProgenitor Cells of the Adult Human White MatterOligodendrocyte LineageAstrocyte LineageSchwann Cell DevelopmentOlfactory Ensheathing CellsSection V: Glial Cell and Myelin Functional BiologyStructure of the Myelinated AxonCell Biology of Myelin AssemblyThe Transport and Assembly of Myelin LipidsFunctional Organization of the Nodes of RanvierElectrophysiologic Consequences of MyelinationRemyelination Through EngraftmentRemyelination by Endogenous Glia