Muscle Biopsy: A Practical Approach

Expert Consult; Online and Print

By

  • Victor Dubowitz, MD, PhD, FRCP, FRCPCH, Emeritus Professor of Paediatrics Dubowitz Neuromuscular Centre Faculty of Medicine Imperial College London Hammersmith Campus London
  • Caroline Sewry, BSc, PhD, FRCPath, Professor of Muscle Pathology, Dubowitz Neuromuscular Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK; Centre for Inherited Neuromuscular Disorders, Department of Histopathology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK
  • Victor Dubowitz, MD, PhD, FRCP, FRCPCH, Emeritus Professor of Paediatrics Dubowitz Neuromuscular Centre Faculty of Medicine Imperial College London Hammersmith Campus London
  • Caroline Sewry, BSc, PhD, FRCPath, Professor of Muscle Pathology, Dubowitz Neuromuscular Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK; Centre for Inherited Neuromuscular Disorders, Department of Histopathology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK

In this book, Professor Victor Dubowitz manages to bridge the gap between clinical syndromes/disorders and their underlying pathologies. An internationally renowned figure in the field of muscle disease, Professor Dubowitz skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment. This reference describes the techniques of obtaining a muscle biopsy and examines the histochemical, histological, electron microscopical and molecular appearance of normal muscle and the pathology of individual muscle disease.
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Audience

Neuropathologists, Neurologists, Pathologists, Residents, Fellows, and Health Science Libraries

 

Book information

  • Published: October 2006
  • Imprint: SAUNDERS
  • ISBN: 978-1-4160-2593-1

Reviews

"The third edition of this book...has surpassed my expectations. The quality of the book overall is excellent, from the production and layout to the illustrations, diagrams and index. The range of muscle diseases included spans both adults and children, with an integrated approach to diagnosis including clinical, genetic, biochemical and pathological features. Overall, this book has been a highlight of the past year for me. It deserves to do very well indeed and will be of immense value beyond its target readership." BMA Awards 2007



Table of Contents

Section 1 The Biopsy: Normal and Diseased Muscle

1. The procedure of muscle biopsy

2. Histological and histochemical stains and reactions

3. Normal muscle

4. Definition of pathological changes seen in muscle biopsies

5. Ultrastructural changes in diseased muscle

6. Immunohistochemistry

7. How to read a biopsy


Section 2 Pathological Muscle: Individual Diseases

8. Classification of neuromuscular disorders

9. Neurogenic disorders

10. Muscular dystrophies and allied disorders I: Duchenne and Becker muscular dystrophy

11. Muscular dystrophies and allied disorders II: limb-girdle muscular dystrophies

12. Muscular dystrophies and allied disorders III: congenital muscular dystrophies

13. Muscular dystrophies and allied disorders IV: Emeryƒ{Driefuss muscular dystrophies and Bethlem myopathy

14. Muscular dystrophies and allied disorders V: facioscapulohumeral dystrophy, myotonic dystrophy, oculopharyngeal muscular dystrophy

15. Congenital myopathies

16. Myofibrillar myopathies

17. Metabolic myopathies I: glycogenoses

18. Metabolic myopathies II: lipid related disorders and mitochondrial myopathies

19. Endocrine disorders

20. Ion channel disorders

21. Myasthenic syndromes

22. Inflammatory myopathies

23. Toxic and drug-induced myopathies
Russell Lane, Charing Cross Hospital


Appendix 1. Glossary of commonly used terms


References


Index