Muscle Biopsy: A Practical Approach book cover

Muscle Biopsy: A Practical Approach

Expert Consult; Online and Print

In this book, Professor Victor Dubowitz manages to bridge the gap between clinical syndromes/disorders and their underlying pathologies. An internationally renowned figure in the field of muscle disease, Professor Dubowitz skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment. This reference describes the techniques of obtaining a muscle biopsy and examines the histochemical, histological, electron microscopical and molecular appearance of normal muscle and the pathology of individual muscle disease.

Neuropathologists, Neurologists, Pathologists, Residents, Fellows, and Health Science Libraries

Hardbound, 626 Pages

Published: October 2006

Imprint: Saunders

ISBN: 978-1-4160-2593-1


  • "The third edition of this book...has surpassed my expectations. The quality of the book overall is excellent, from the production and layout to the illustrations, diagrams and index. The range of muscle diseases included spans both adults and children, with an integrated approach to diagnosis including clinical, genetic, biochemical and pathological features. Overall, this book has been a highlight of the past year for me. It deserves to do very well indeed and will be of immense value beyond its target readership." BMA Awards 2007


  • Section 1 The Biopsy: Normal and Diseased Muscle

    1. The procedure of muscle biopsy

    2. Histological and histochemical stains and reactions

    3. Normal muscle

    4. Definition of pathological changes seen in muscle biopsies

    5. Ultrastructural changes in diseased muscle

    6. Immunohistochemistry

    7. How to read a biopsy

    Section 2 Pathological Muscle: Individual Diseases

    8. Classification of neuromuscular disorders

    9. Neurogenic disorders

    10. Muscular dystrophies and allied disorders I: Duchenne and Becker muscular dystrophy

    11. Muscular dystrophies and allied disorders II: limb-girdle muscular dystrophies

    12. Muscular dystrophies and allied disorders III: congenital muscular dystrophies

    13. Muscular dystrophies and allied disorders IV: Emeryƒ{Driefuss muscular dystrophies and Bethlem myopathy

    14. Muscular dystrophies and allied disorders V: facioscapulohumeral dystrophy, myotonic dystrophy, oculopharyngeal muscular dystrophy

    15. Congenital myopathies

    16. Myofibrillar myopathies

    17. Metabolic myopathies I: glycogenoses

    18. Metabolic myopathies II: lipid related disorders and mitochondrial myopathies

    19. Endocrine disorders

    20. Ion channel disorders

    21. Myasthenic syndromes

    22. Inflammatory myopathies

    23. Toxic and drug-induced myopathies
    Russell Lane, Charing Cross Hospital

    Appendix 1. Glossary of commonly used terms




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