Muscle 2-Volume Set book cover

Muscle 2-Volume Set

Fundamental Biology and Mechanisms of Disease

A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte.


Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit.


The primary audience for this work is entry level and experienced researchers, practicing clinicians, postdocs, graduate students, and medical students across molecular and muscle medicine, developmental biology, molecular biology, cell biology, physiology, pathology, pharmacology, cardiology, translational medicine and biomedicine.

Hardbound, 1528 Pages

Published: July 2012

Imprint: Academic Press

ISBN: 978-0-12-381510-1


  • "This two-volume set is distinguished by its emphasis on normal muscle function as well as changes evident in pathology or disease. Therapeutic interventions end each section, but the science comes first. Organization of 108 chapters is in sections on cardiac muscle (basic physiology, adaptations and response, myocardial disease); skeletal muscle (basics and adaptations, disease, and therapeutics); and smooth muscle (physiology, heterogeneities, adaptations and response, and disease). Editors Hill and Olson (both: U. of Texas Southwestern Medical Center) have shepherded the work of contributors based mostly in the US, with a few from Europe."--Reference & Research Book News October 2012


  • Part 1: Introduction

    1. An Introduction to Muscle

    2. A History of Muscle


    Part II: Cardiac Muscle

    Section A: Basic Physiology

    3. Cardiac Myocyte Specification and Differentiation

    4. Transcriptional Control of Cardiogenesis

    5. Cardiomyocyte Ultrastructure

    6. Overview of CArdiac Muscle Physiology

    7. Ionic Fluxes and Genesis of the Cardiac Action Potential

    8. G-Protein-Coupled Receptors in the Heart

    9. Receptor Tyrosine Kinases in Cardiac Muscle

    10. Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network

    11. Calcium Fluxes and Homeostasis

    12. Excitation-Contraction Coupling in the Heart

    13. Role of Sarcomeres in Cellular Tension, Shortening, and Signaling in Cardiac Muscle

    14. Cardiovascular Mechanotransduction

    15. Cardiomyocyte Metabolism: All Is in Flux

    16. Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function

    17. Mitochondrial Morphology and Function

    18. Genetics and Genomics in Cardiovascular Gene Discovery

    19. Cardiovascular Proteomics: Assessment of Protein Post-Translational Modifications

    Section B: Adaptations and Response

    20. Adaption and Responses: Myocardial Innervations adn Neural Control

    21. Regulation of Cardiac Systolic Function and Contractility

    22. Intracellular Signaling Pathways in Cardiac Remodeling

    23. Oxidative Stress and Cardiac Muscle

    24. Physiologic and Molecular Responses of the Heart to Chronic Exercise

    25. Epigenetics in Cardiovascular Biology

    26. Cardiac MicroRNAs

    27. Protein Quality Control in Cardiomyocytes

    28. Cardioprotection

    29. Cardiac Fibrosis: Cellular and Molecular Determinants

    30. Autophagy in Cardiac Physiology and Disease

    31. Programmed Cardiomyocyte Death in Heart Disease

    32. Wnt and Notch: Potent Regulators of Cardiomyocyte Specification, Proliferation, and Differentiation

    Section C: Myocardial Disease

    33. Congenital Cardiomyopathies

    34. Genetics of Congenital Heart Disease

    35. Mechanisms of Stress-Induced Cardiac Hypertrophy

    36. Ischemic Heart Disease

    37. The Pathophysiology of Heart Failure

    38. The Right Ventricle: Reemergence of the Forgotten Ventricle

    39. Mammalian Myocardial Regeneration

    40. The Structural Basis of Arrhythmia

    41. Molecular and Cellular Mechanisms of Cardiac Arrhythmias

    42. Genetic Mechanisms of Arrhythmia

    43. Infiltrative adn Protein Misfolding Myocardial Diseases

    44. Cardiac Aging: From Humans to Molecules

    45. Adrenergic Receptor Polymorphisms in Heart Failure

    46. Cardiac Gene Therapy

    47. Protein Kinases in the Heart: Lessons Learned from Targeted Cancer Therapeutics

    48. Cell Therapy for Cardiac Disease

    49. Chemical Genetics of Cardiac Regeneration

    50. Device Therapy for Systolic Ventricular Failure

    51. Novel Therapeutic Targets and Strategies against Myocardial Diseases


    Part III: Skeletal Muscle

    Section A: Basic Physiology

    52. Skeletal Muscle Development

    53. Skeletal Muscle: Architecture of Membrane Systems

    54. The Vertebrate Neuromuscular Junction

    55. Neuromuscular Interactions that Control Muscle Function and Adaptation

    56. Control of Resting CA2+ Concentration in Skeletal Muscle

    57. Skeletal Muscle Excitation-Contraction Coupling

    58. The Contractile Machinery of Skeletal Muscle

    59. Skeletal Muscle Metabolism

    60. Skeletal Muscle Fiber Types

    Section B: Adaptations and Response

    61. Regulation of Skeletal Muscle Development and Function by microRNAs

    62. Musculoskeletal Tissue Injury and Repair: Role of Stem Cells, Their Differentiation, and Paracrine Effects

    63. Immunological Responses to Muscle Injury

    64. Skeletal Muscle Adaptation to Exercise

    65. Skeletal Muscle Regeneration

    66. Skeletal Muscle Dystrophin-Glycoprotein Complex and Muscular Dystrophy

    Section C: Skeletal Muscle Disease

    67. Statin-Induced Muscle Toxicity: Clinical and Genetic Determinants of Risk

    68. Myotonic Dystrophy

    69. Facioscapulohumeral Muscular Dystrophy: Unraveling the Mysteries of a Complex Epigenetic Disease

    70. ECM-Related Myopathies and Muscular Dystrophies

    71. Molecular Pathogenesis of Skeletal Muscle Abnormalities in Marfan Syndrome

    72. Diseases of the Nucleoskeleton

    73. Channelopathies of Skeletal Muscle Excitability

    74. Thick and Thin Filament Proteins: Acquired adn Hereditary Sarcomeric Protein Diseases

    75. Metabolic and Mitochondrial Myopathies

    Section D: Therapeutics

    76. Gene Therapy of Skeletal Muscle Disorders Using Viral Vectors

    77. Cell-Based Therapies in Skeletal Muscle Disease

    78. Immunological Components of Genetically Inherited Muscular Dystrophies: Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy

    79. Myostatin: Regulation, Function, and Therapeutic Applications

    80. Insulin-Like Growth Factor I Regulation and Its Action in Skeletal Muscle Growth and Repair

    81. Novel Targets and Approaches to Treating Skeletal Muscle Disease


    Part IV: Smooth Muscle

    Section A: Basic Physiology

    82. Development of the Smooth Muscle Cell Lineage

    83. Smooth Muscle Myocyte Ultrastructure

    84. Potassium, Sodium, and Chloride Channels in Smooth Muscle Cells

    85. G-Protein-Coupled Receptors in Smooth Muscle

    86. Calcium Homeostasis and Signaling in Smooth Muscle

    87. Regulation of Smooth Muscle Contraction

    Section B: Heterogeneities

    88. Heterogeneity of Smooth Muscle

    89. Microcirculation

    90. Uterine Smooth Muscle

    Section C: Adaptations and Response

    91. Oxidative Stres, Endothelial Dysfunction, and Its Impact on Smooth Muscle Signaling

    92. Hemodynamic Control of Vascular Smooth Muscle Function

    93. Myogenic Tone and Mechanotransduction

    94. Cell-Cell Communication Through Gap Junctions

    95. Vascular Smooth Muscle Cell Phenotypic Adaptation

    96. Molecular Pathways of Smooth Muscle Disease

    Section D: Smooth Muscle Disease

    97. Genetic Variants in Smooth Muscle Contraction and Adhesion Genes Cause Thoracic Aortic Aneurysms and Dissections and Other Vascular Diseases

    98. Vascular Smooth Muscle Cell Remodeling in Atherosclerosis and Restenosis

    99. Arterial Hypertention

    100. Diabetic Vascular Disease

    101. Vascular Mechanisms of Hypertension in the Pathophysiology of Preeclampsia

    102. Erectile Dysfunction

    103. Smooth Muscle in the Normal and Diseased Pulmonary Circulation

    104. Airway Smooth Muscle and Asthma

    105. Aging

    106. Vascular Calcification

    107. Smooth Muscle Progenitor Cells: A Novel Target for the Treatment of Vascular Disease?

    108. Smooth Muscle: Novel Targets and Therapeutic Approaches



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