Multiscale Modeling of Developmental Systems book cover

Multiscale Modeling of Developmental Systems

Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation.This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists - especially graduate students and post-docs, from both biological and quantitative backgrounds.

Graduate students and scientists in developmental biology, mathematical sciences, biomathematics, and general life sciences.

Hardbound, 604 Pages

Published: December 2007

Imprint: Academic Press

ISBN: 978-0-12-374253-7


  • Chapter 1IntroductionPhilip K. Maini, Stuart A. Newman, Timothy J. Newman and Santiago SchnellChapter 2Models of biological pattern formation: from elementary steps to the organization of embryonic axesHans MeinhardtChapter 3Robustness of embryonic spatial patterning in Drosophila melanogasterDavid Umulis, Michael B. O’Connor and Hans G. OthmerChapter 4Integrating morphogenesis with underlying mechanics and cell biology.Lance A. DavidsonChapter 5The mechanisms underlying primitive streak formation in the chick embryoManli Chuai, Cornelis J WeijerChapter 6Grid-free models of multicellular systems, with an application to large-scale vortices accompanying primitive streak formationT. J. NewmanChapter 7Mathematical models for somite formationRuth E. Baker, Santiago Schnell and Philip K. MainiChapter 8Coordinated Action of N-CAM, N-cadherin, EphA4 and ephrinB2 Translates Genetic Prepatterns into Structure during Somitogenesis in ChickJames A. Glazier, Ying Zhang, Maciej Swat, Benjamin Zaitlen, Santiago Schnell Chapter 9Branched organs: Mechanics of morphogenesis by multiple mechanismsSharon R LubkinChapter 10Multicellular sprouting during vasculogenesisAndras Czirok, Evan A. Zamir, Andras Szabo and Charles D. LittleChapter 11Modelling lung branching morphogenesisTakashi MiuraChapter 12Multiscale Models for Vertebrate Limb DevelopmentStuart A. Newman, Scott Christley, Tilmann Glimm, H.G.E. Hentschel, Bogdan Kazmierczak, Yong-Tao Zhang, Jianfeng Zhu and Mark AlberChapter 13Tooth morphogenesis in vivo, in vitro and in silicoIsaac Salazar-CiudadChapter 14Cell mechanics with a 3D kinetic and dynamic weighted Delaunay-triangulationMichael Meyer-HermannChapter 15Cellular automata as microscopic models of cell migration in heterogeneous environmentsH. Hatzikirou and A. DeutschChapter 16Multiscale modeling of biological pattern formationRamon GrimaChapter 17Relating Biophysical Properties Across ScalesElijah Flenner, Francoise Marga, Adrian Neagu, Ioan Kosztin, Gabor ForgacsChapter 18Complex Multicellular Systems and Immune Competition: New Paradigms Looking for aMathematical TheoryN. Bellomo, G. Forni


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