Multiple Sclerosis As A Neuronal Disease book cover

Multiple Sclerosis As A Neuronal Disease

This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities.

Neurologists, neuroscientists, and clinical and basic researchers studying multiple sclerosis.

Hardbound, 496 Pages

Published: April 2005

Imprint: Academic Press

ISBN: 978-0-12-738761-1


  • "The editor and many excellent contributors present abundant evidence for importance of the neuronal component of multiple sclerosis. ...There is no doubt that Steve Waxman's forceful book will substantially influence the field by providing a strong impetus to research on the neuronal question in multiple sclerosis." --NATURE NEUROSCIENCE (February 2006) "...this book offers an excellent overview of the biology of the axon, the clinical assessment of axonal damage, and the mechanisms contributing to axonal damage. ...The book should provide valuable reading for the student of neurology as well as for those less familiar with the subtleties of the axon. It will also be of value to those knowledgeable about multiple sclerosis who are beginning to move into clinical studies of neuroprotection and repair." --Henry McFarland in THE NEW ENGLAND JOURNAL OF MEDICINE (September 22, 2005) "'MS as a Neuronal Disease' by Waxman and coauthors is a textbook long overdue. ...This book makes essential reading for neuroscientists and neurologists" --Archives of Neurology (December 2005)


  • Preface


    I Structure, Molecular Organization, and Function of Myelinated Axons

    1. The Structure of Myelinated Axons in the CNS

    2. Dialogues: Communication Between Axons and Myelinating Glia

    3. Molecular Specializations at the Glia-Axon Interface

    4. Potassium Channel Organization of Myelinated and Demyelinated Axons

    5. The Roles of Potassium and Calcium Channels in Physiology and Pathophysiology of Axons

    II Neuronal Concomitants of Demyelination

    6. The Conduction Properties of Demyelinated and Remyelinated Axons

    7. Altered Distributions and Functions of Multiple Sodium Channel Subtypes in Multiple Sclerosis and Its Models

    8. Na+ Channel Reorganization in Demyelinated Axons

    9. Ion Currents and Axonal Oscillators: A Possible Biophysical Basis for Positive Signs and Symptoms in Multiple Sclerosis

    10. Clinical Pharmacology of Abnormal Potassium Channel Organization in Demyelinated Axons

    III Multiple Sclerosis as a Neurodegenerative Disease

    11. Pathology of Neurons in Multiple Sclerosis

    12. Axonal Degeneration in Multiple Sclerosis: The Histopathological Evidence

    13. Natural History of Multiple Sclerosis: When Do Axons Degenerate?

    IV Measurement of Neuronal Changes in the Clinical Domain

    14. Brain Atrophy as a Measure of Neurodegeneration and Neuroprotection

    15. MRI-Clinical Correlations in Multiple Sclerosis: Implications for Our Understanding of Neuronal Changes

    16. Electrophysiological Correlates of Relapse, Remission, Persistent Sensorimotor Deficit, and Long-Term Recovery Processes in Multiple Sclerosis

    V Cellular and Molecular Mechanisms of Axonal Degeneration in Multiple Sclerosis

    17. Inflammation and Axon Degeneration

    18. Nitric Oxide and Axonal Pathophysiology

    19. Molecular Mechanisms of Calcium Influx in Axonal Degeneration

    20. Axonal Damage and Neuron Death in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: The Role of Calpain

    21. Mutations of Myelination-Associated Genes That Affect Axonal Integrity

    VI Other Aspects of Neuronal Injury in Multiple Sclerosis

    22. Neuronal Blocking Factors in Demyelinating Diseases

    23. Evidence for Neuronal Apoptosis in Demyelinating CNS Diseases

    VII Lessons from the Peripheral Nervous System

    24. Mechanisms Underlying Wallerian Degeneration

    25. AMAN: What It Teaches Us about Mechanisms Underlying Axonal Injury

    VIII Prognosis, Reparative Mechanisms, and Therapeutic Approaches

    26. Axonal Degeneration as a Predictor of Outcome in Neurological Disorders

    27. Remyelination as Neuroprotection

    28. Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons

    29. Blocking the Axonal Injury Cascade: Neuroprotection in Multiple Sclerosis and Its Models

    30. Functional Brain Reorganization and Recovery after Injury to White Matter



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