Multiple Sclerosis As A Neuronal Disease


  • Stephen Waxman, Yale University School of Medicine, CT, USA

This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities.
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Neurologists, neuroscientists, and clinical and basic researchers studying multiple sclerosis.


Book information

  • Published: April 2005
  • ISBN: 978-0-12-738761-1


"The editor and many excellent contributors present abundant evidence for importance of the neuronal component of multiple sclerosis. ...There is no doubt that Steve Waxman's forceful book will substantially influence the field by providing a strong impetus to research on the neuronal question in multiple sclerosis." --NATURE NEUROSCIENCE (February 2006) "...this book offers an excellent overview of the biology of the axon, the clinical assessment of axonal damage, and the mechanisms contributing to axonal damage. ...The book should provide valuable reading for the student of neurology as well as for those less familiar with the subtleties of the axon. It will also be of value to those knowledgeable about multiple sclerosis who are beginning to move into clinical studies of neuroprotection and repair." --Henry McFarland in THE NEW ENGLAND JOURNAL OF MEDICINE (September 22, 2005) "'MS as a Neuronal Disease' by Waxman and coauthors is a textbook long overdue. ...This book makes essential reading for neuroscientists and neurologists" --Archives of Neurology (December 2005)

Table of Contents



I Structure, Molecular Organization, and Function of Myelinated Axons

1. The Structure of Myelinated Axons in the CNS

2. Dialogues: Communication Between Axons and Myelinating Glia

3. Molecular Specializations at the Glia-Axon Interface

4. Potassium Channel Organization of Myelinated and Demyelinated Axons

5. The Roles of Potassium and Calcium Channels in Physiology and Pathophysiology of Axons

II Neuronal Concomitants of Demyelination

6. The Conduction Properties of Demyelinated and Remyelinated Axons

7. Altered Distributions and Functions of Multiple Sodium Channel Subtypes in Multiple Sclerosis and Its Models

8. Na+ Channel Reorganization in Demyelinated Axons

9. Ion Currents and Axonal Oscillators: A Possible Biophysical Basis for Positive Signs and Symptoms in Multiple Sclerosis

10. Clinical Pharmacology of Abnormal Potassium Channel Organization in Demyelinated Axons

III Multiple Sclerosis as a Neurodegenerative Disease

11. Pathology of Neurons in Multiple Sclerosis

12. Axonal Degeneration in Multiple Sclerosis: The Histopathological Evidence

13. Natural History of Multiple Sclerosis: When Do Axons Degenerate?

IV Measurement of Neuronal Changes in the Clinical Domain

14. Brain Atrophy as a Measure of Neurodegeneration and Neuroprotection

15. MRI-Clinical Correlations in Multiple Sclerosis: Implications for Our Understanding of Neuronal Changes

16. Electrophysiological Correlates of Relapse, Remission, Persistent Sensorimotor Deficit, and Long-Term Recovery Processes in Multiple Sclerosis

V Cellular and Molecular Mechanisms of Axonal Degeneration in Multiple Sclerosis

17. Inflammation and Axon Degeneration

18. Nitric Oxide and Axonal Pathophysiology

19. Molecular Mechanisms of Calcium Influx in Axonal Degeneration

20. Axonal Damage and Neuron Death in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: The Role of Calpain

21. Mutations of Myelination-Associated Genes That Affect Axonal Integrity

VI Other Aspects of Neuronal Injury in Multiple Sclerosis

22. Neuronal Blocking Factors in Demyelinating Diseases

23. Evidence for Neuronal Apoptosis in Demyelinating CNS Diseases

VII Lessons from the Peripheral Nervous System

24. Mechanisms Underlying Wallerian Degeneration

25. AMAN: What It Teaches Us about Mechanisms Underlying Axonal Injury

VIII Prognosis, Reparative Mechanisms, and Therapeutic Approaches

26. Axonal Degeneration as a Predictor of Outcome in Neurological Disorders

27. Remyelination as Neuroprotection

28. Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons

29. Blocking the Axonal Injury Cascade: Neuroprotection in Multiple Sclerosis and Its Models

30. Functional Brain Reorganization and Recovery after Injury to White Matter