Multiple Sclerosis and Related Disorders book cover

Multiple Sclerosis and Related Disorders

Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab)

Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system.  While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets.  MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS.  This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners.

Neuroscience research workers

Hardbound, 736 Pages

Published: March 2014

Imprint: Elsevier

ISBN: 978-0-444-52001-2


  • Section 1 Pathogenesis
    1. Immune regulation of multiple sclerosis  
    2. Neuropathology of MS 
    3. The good and the bad of neuroinflammation in multiple sclerosis 
    4. Demyelination in multiple sclerosis 
    5. Axonal Loss in Multiple Sclerosis: Causes and Mechanisms  
    6. Insights from magnetic resonance imaging 
    7. Infections and multiple sclerosis 
    8. The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment

    Section 2 Epidemiology and genetics
    9. Multiple sclerosis genetics 
    10. Genetics of primary progressive multiple sclerosis 
    11. The epidemiology of multiple sclerosis: insights to disease pathogenesis

    Section 3 Diagnosis and disease course
    12. Multiple Sclerosis: Diagnosis, Differential Diagnosis and Clinical Presentation 
    13. MRI mimics of multiple sclerosis 
    14. Diagnosis of multiple sclerosis 
    15. Clinical course of multiple sclerosis 
    16. Early prognosis of multiple sclerosis 
    17. Clinical outcome measures in Multiple Sclerosis 
    18. MRI outcomes in the diagnosis and disease course of multiple sclerosis  
    19. Multiple sclerosis in children

    Section 4 Treatment
    20. Clinical trials in multiple sclerosis 
    21. Glucocorticoid treatment of multiple sclerosis 
    22. Disease Modifying Agents in Multiple Sclerosis 
    23. Immunosuppressive treatments in multiple sclerosis 
    24. Symptomatic treatment and management of multiple sclerosis 
    25. Future Treatment Approaches to multiple sclerosis 

    Section 5 Other demyelinating diseases
    26. Neuromyelitis Optica (Devic's Syndrome) 
    27. Acute disseminated encephalomyelitis and other inflammatory demyelinating variants 
    28. Acute inflammatory myelopathies 

    Section 6 Capita selecta
    29. Clinical Neurophysiology of multiple sclerosis 
    30. Cerebrospinal fluid analysis


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