Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders

Edited by

  • Robert McArthur, McArthur & Associates GmbH, Basel, Switzerland
  • Franco Borsini, Head, Central & Peripheral Nervous System and General Pharmacology Area - R&D Department, sigma-tau SpA, Pomezia (Rome), Italy

Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. Reward Deficit Disorders also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.

This is the third volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually.

Hardbound, 432 Pages

Published: October 2008

Imprint: Academic Press

ISBN: 978-0-12-373860-8

  • Preface to Reward Deficit Disorders Volume: What Do You Mean By “Translational Research”? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders Robert A McArthur and Franco Borsini 1. C. Heidbreder. Impulse and Reward Deficit Disorders: Drug Discovery and Development 2. D. McCann et al. Drug Discovery and Development for Reward Disorders: Views from Government 3. T. Gardner et al. Issues in Designing and Conduction Clinical Trails for Reward Disorders: A Clinical View 4. G. Koob. The Role of Animal Models in Reward Deficit Disorders: Views of Academia 5. Hilary J Little et al. Pharmacotherapy of Alcohol Dependence: Improving Translation from the Bench to the Clinic 6. A. Markou et al. Contribution of Animal Models and Preclinical Human Studies to Medication: Development for Nicotine Dependence 7. B. Rocha et al. Development of Medication for Heroin and Cocaine Addiction and Regulatory Aspects of Abuse Liability Testing 8. C. Dourish et al. Anti-obesity Drugs: From Animal Models to Clinical Efficacy 9. W. Williams et al. Current Concepts in the Classification, Treatment and Modeling of Pathological Gambling and other Impulse Control Disorders Epilogue: Translational Models for the 21st century: Reminiscence, Reflections and Some Recommendations Paul Willner, Franco Borsini, and Robert A McArthur

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