Animal and Translational Models for CNS Drug DiscoveryEdited by
- Robert McArthur, McArthur & Associates GmbH, Basel, Switzerland
- Franco Borsini, Head, Central & Peripheral Nervous System and General Pharmacology Area - R&D Department, sigma-tau SpA, Pomezia (Rome), Italy
Minimize the number of drug candidates that could later fail in human trials! These three volumes provide a unique examination of how animal models are evolving from ?behavioral gut baths? to providing cross-species information relevant to human clinical responses. Each volume provides the views and experiences of leading pre-clinical and clinical investigators who are actively involved in translational research and experimental medicine.Each volume is devoted to specific disorders in three scientific fields: Psychiatric, Neurological, and Reward Deficit.
Academic neuroscientists involved in the development and use of animal models of neuropsychiatric disorders to study their basic neurobiology; Academic and pharmaceutical neuroscientists involved in the use of animal models of neuropsychiatric disorders to identify and validate novel targets for potential pharmaceutical treatment of these disorders; Clinical and translational neuroscientists concerned with limitations of present neuropsychiatric clinical trial designs, development of valid biomarkers and cross-species; and Pharmaceutical industry, regulatory body and venture capital executives concerned with improvements in the attrition rate of CNS drug candidates.
Imprint: Academic Press
- "These volumes therefore represent the latest, most comprehensive information and perspectives as well as source material for animal models as they relate to issues and concepts in translational medicine." -- James E. Barrett, Drexel University College of Medicine, Philadelphia, PA
- VOLUME 1: Pyschiatric Disorders Preface: What Do You Mean By ?Translational Research?? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders Robert A McArthur and Franco Borsini 1. Mark J. Millan. The Discovery and Development of Pharmacotherapy for Psychiatric Disorders: A Critical Survey of Animal and Translational Models, and Perspectives for their Improvement 2. L. Winsky et al. Drug Discovery and Development Initiatives at the National Institute of Mental Health: From Cell-Based System to Proof of Concept 3. J. McEvoy and Freudenreich. Issues in the Design and Conductance of Clinical Trials 4. Klaus A. Miczek. Challenges for Translational Psychopharmacology Research – The Need for Conceptual Principles 5. T. Steckler et al. Developing Novel Anxiolytics: Improving Preclinical Detection and Clinical Assessment 6. D. Joel et al. Animal Models of Obsessive-Compulsive Disorder: From Bench to Beside Via Endophenotypes and Biomarkers 7. J. Cryan et al. Developing More Efficacious Antidepressant Medications: Improving and Aligning Preclinical and Clinical Assessment Tools 8. D. Jones et al. Developing New Drugs for Schizophrenia: From Animals to the Clinic 9. C. Large et al. Developing Therapeutics for Bipolar Disorder (BPD): From Animal Models to the Clinic 10. R. Tannock et al. Towards a Biological Understanding of ADHD and the Discovery of Novel Therapeutic Approaches 11. J. Bartz et al. Preclinical Animal Models of Autistic Spectrum Disorders (ASD) 12. S. Doran et al. Translational Models of Sleep and Sleep Disorders Epilogue: Translational Models for the 21st century: Reminiscence, Reflections and Some Recommendations VOLUME 2: Neurological Disorders Preface: What Do You Mean By ?Translational Research?? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Neurological Disorders Robert A McArthur and Franco Borsini 1. A. Jackie Hunter. Animal and Translational Models of Neurological Disorders: An Industrial Perspective 2. Lon S Schneider. Issues in Design and Conduct of Clinical Trials for Cognitive-Enhancing Drugs 3. C. Shilyansky et al. Molecular And Cellular Mechanisms Of Learning Disabilities: A Focus On Neurofibromatosis Type I 4. M. Lindner et al. Development, Optimization and Use of Preclinical Behavioral Models to Maximize the Productivity of Drug Discovery for Alzheimer's Disease 5. K. Merchant et al. Animal Models of Parkinson's Disease to Aid Drug Discovery and Development 6. T. Wagner et al. Huntington Disease 7. J. Montes. Translational Research in ALS 8. H. Klitgaard. Animal and Translational Models of the Epilepsies Epilogue: Translational Models for the 21st century: Reminiscence, Reflections and Some Recommendations Paul Willner, Franco Borsini, and Robert A McArthur VOLUME 3: Reward Deficit Disorders Preface: What Do You Mean By ?Translational Research?? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders Robert A McArthur and Franco Borsini 1. C. Heidbreder. Impulse and Reward Deficit Disorders: Drug Discovery and Development 2. D. McCann et al. Drug Discovery and Development for Reward Disorders: Views from Government 3. T. Gardner et al. Issues in Designing and Conduction Clinical Trails for Reward Disorders: A Clinical View 4. G. Koob. The Role of Animal Models in Reward Deficit Disorders: Views of Academia 5. Hilary J Little et al. Pharmacotherapy of Alcohol Dependence: Improving Translation from the Bench to the Clinic 6. A. Markou et al. Contribution of Animal Models and Preclinical Human Studies to Medication: Development for Nicotine Dependence 7. B. Rocha et al. Development of Medication for Heroin and Cocaine Addiction and Regulatory Aspects of Abuse Liability Testing 8. C. Dourish et al. Anti-obesity Drugs: From Animal Models to Clinical Efficacy 9. W. Williams et al. Current Concepts in the Classification, Treatment and Modeling of Pathological Gambling and other Impulse Control Disorders Epilogue: Translational Models for the 21st century: Reminiscence, Reflections and Some Recommendations Paul Willner, Franco Borsini, and Robert A McArthur