Genetics and ModelsEdited by
- Mark LeDoux
The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.
General neurologists, neurologists with subspecialty interest in movement disorders, neuroscientists, rehabilitation physicians, psychiatrists, and academic veterinarians with an interest in animal models.
Hardbound, 800 Pages
Published: September 2014
Imprint: Academic Press
"The book is a timely review of animal models of movement disorders...The text is an excellent resource for neurologists and researchers specializing in movement disorders. In addition, this book will undoubtedly be a useful reference source for general neurologists, neurology residents, and basic science fellow and students." - Zbigniew K. Wszolek, Department of Neurology, Mayo Clinic Jacksonville in PARKINSONISM AND RELATED DISORDERS (September 2005) "...this new textbook provides a comprehensive treatment of animal models used to study human movement disorders and should serve the neurologist, researcher, and other interested scientists very well." --Dr. A.S. Fix, Central Product Safety, The Proctor and Gamble Co, Miami Valley Innovation Center, Cincinnati, OH, in VETERINARY PATHOLOGY (43:5) 2006
- Section I. Scientific Foundations; A1 Disorders of Motor Control: Motor Syndromes and Involuntary Movements; A2 Modeling Disorders of Movement; A3 New Transgenic Technologies; A4 Assessment of Movement Disorders in Rodents; A5 Drosophila; A6 C. elegans; A7 Zebrafish; A8 Techniques of Motor Assessment in Rodents; A9 Non-motor Assessment of Rodents; A10 Induced pluripotent stem cells (iPSCs); A11 Neurophysiological Assessment of Movement in Humans; A12 Neurophysiological and Optogenetic Assessment of Motor Networks; A13 Functional Imaging to Study Movement Disorders in Human and Non-Human Models; A14 Intraopertive Neurophysiology to Understand Pathophysiology; Section II. Parkinson Disease; B1 Motor and Non-Motor Features of Parkinson Disease; B2 Genetics of Parkinson Disease; B3 Genotype-Phenotype Correlations in Parkinson Disease; B4 MPTP, Neurotoxin and Viral (Exogenous) Models of PD; B5 Rodent Models of Autosomal Dominant PD; B6 Rodent Models of Autosomal Recessive PD; B7 Drosophila models of PD; B8 Primates Models of PD-Treatment Related Complications; B9 MitoPark Mouse; B10 E3 Ubiquitin Ligase Element SKP1A KD; B11 Models of Levodopa-Induced Dyskinesias; Section III. Dystonia; C1 Dystonia Phenotypes and Genetics; C2 The Genetically Dystonic Rat; C3 Models of Focal Dystonia; C4 Spontaneous Mutant Murine Models of Dystonia; C5 Rodent Models of Autosomal Dominant Primary Dystonia; C6 Modeling Dystonia-Parkinsonism; Section IV. Huntington Disease; D1 Genetics of HD and HD-like Disorders; D2 Murine Models of HD; D3 Use of Genetically Engineered Mice to Study the Biology of Huntington; D4 Modeling HD in Yeast and Invertebrates; D5 HDL2 Mouse; Section V. Tremor; E1 Essential Tremor: Genetics and Clinical Features; E2 Physiological Assessment of Tremor in Rodents; E3 Harmaline Tremor; E4 Mouse Models of Fragile X Tremor/Ataxia Syndrome; Section VI. Myoclonus; F1 Classification, Clinical Features and Genetics; F2 Mouse Models of PME; F3 Rat Model of Posthypoxic Myoclonus; F4 Generating Mouse Models of Mitochondrial Disease; Section VII. Tics; G1 Tics and Tourette Syndrome: Phenomenology; G2 Genetics of Tourette Syndrome; G3 Tics and Striatal Fast Spiking Interneurons; G4 Mouse Models to Study OCD; Section VIII. Paroxysmal Movement Disorders; H1 Classification and Genetics; H2 PNKD; H3 Glut1 Haploinsufficiency; H4 EA1 and Kv1.1 Null Mice; H5 EA2; Section IX. Tauopathies; I1 Classification and Genetics (Role of Tau in PD); I2 Drosophila Models of Tauopathy; I3 Rodent Models of Tauopathy; I4 Cell and Molecular Biology of Tau; Section X. Other Parkinsonian Syndromes; J1 Overview of Clinical Phenomenology and Genetics; J2 MSA; J3 NBIA Pantothenate kinase-associated neurodegeneration: insights from Drosophila Models; J4 PLA2G6 knock-out; Section XI. Ataxias; K1 Genetics and Clinical Features of Hereditary Ataxias; K2 Models of SCA1; K3 SCA3 and Other Autosomal Dominant Ataxias; K4 FA- Murine and Cellular Models; K5 Other Recessive Ataxias; K6 Drosophila Models of FA; K7 C. elegans models to study the molecular biology of ataxia; K8 Untitled; Section XII. Hereditary Spastic Paraplegia; L1 Genetics and Clinical Features; L2 AD Murine Models of HSP; L3 AR Murine Models of HSP; L4 Zebrafish Models of HSP; L5 Drosophila Models of HSP; L6 C. elegans Models of HSP; L7 Use of Arabidopsis to Model HSP; Section XIII. Restless Legs Syndrome; M1 Genetics and Clinical Features; M2 Combined D/ Iron Deficient Mouse Model; M3 Combined A11/Iron Deficient Mouse Model