Motor Neuron Disorders and Related Diseases book cover

Motor Neuron Disorders and Related Diseases

Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab)

This volume provides a comprehensive and scholarly accounting of motor neuron disorders, a group of diseases that are both clinically and genetically diverse. Clinicians and neuroscientists alike will find invaluable research and information on recent advancements that have occurred in the understanding of these disorders.

From specific discussions of their underlying molecular pathogenesis, to advancements in therapies and diagnosis, users will find a resource that presents a comprehensive understanding of the general clinical features and management of these devastating disorders. In addition, new tactics that can be used to enhance patient care are also presented and discussed.

Specific chapters within the volume include discussions pertaining to the historical aspects of motor neuron diseases, comparative anatomy, physiology, and development of the corticospinal system, and discussions of spinal muscular atrophies, amongst others. In addition, symptomatic therapy and the palliative aspects of clinical patient care are also presented.

Audience
Neurologists
Neuroscience research workers

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Published: December 2006

Imprint: Elsevier

ISBN: 978-0-444-51894-1

Contents

  • 1. Historical aspects of motor neuron diseases, Andrew A. Eisen (Vancouver, Canada)

    SECTION 1 Basic aspects

    2. Comparative anatomy and physiology of the corticospinal system, Marc H. Schieber (Rochester, NY, USA)

    3. Development of the corticospinal system and spinal motor circuits, John H. Martin (New York, NY, USA)

    4. Molecular mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis, Siân C. Barber and Pamela J. Shaw (Sheffield, UK)

    5. Cytopathology of the motor neuron, Paul G. Ince and Stephen B. Wharton (Sheffield, UK)

    6. Animal models of motor neuron death, Jean-Pierre Julien and Jasna Kriz (Quebec, Canada)

    SECTION 2 Anterior horn cell disorders and motor neuropathies

    7. Spinal muscular atrophies and hereditary motor neuropathies, Kevin Talbot and Kay E. Davies (Oxford, UK)

    8. Spinobulbar muscular atrophy (Kennedy’s disease), Jean-Marc Gallo and P. Nigel Leigh (London, UK)

    9. GM2 gangliosidoses, Amos D. Korczyn (Ramat-Aviv, Israel)

    10. Viral infections of lower motor neurons, Tom Solomon, Mong How Ooi and Macpherson Mallewa (Liverpool, UK and Sarawak, Malaysia)

    11. Monomelic amyotrophy of upper or lower limbs, M. Gourie-Devi (New Delhi, India)

    12. Multifocal and other motor neuropathies, Leonard H. van den Berg, Hessel Franssen, Jan-Thies H. van Asseldonk, Renske M. van den Berg-Vos and John H. J. Wokke (Utrecht, The Netherlands)

    SECTION 3 Amyotrophic lateral sclerosis

    13. Amyotrophic lateral sclerosis, P. Nigel Leigh (London, UK)

    14. Familial amyotrophic lateral sclerosis, Christopher E. Shaw, Virginia Arechavala-Gomeza and Ammar Al-Chalabi (London, UK)

    15. Juvenile amyotrophic lateral sclerosis, Paul Orban, Rebecca S. Devon, Michael R. Hayden and Blair R. Leavitt (Vancouver, Canada and Edinburgh, UK)

    SECTION 4 Corticospinal disorders

    16. Primary lateral sclerosis, Andrew A. Eisen (Vancouver, Canada)

    17. Hereditary spastic paraparesis, Christopher J. McDermott and Pamela J. Shaw (Sheffield, UK)

    18. Toxic disorders of the upper motor neuron system, D. Desire Tshala-Katumbay and Peter S. Spencer (Portland, OR, USA)

    SECTION 5 Therapeutic aspects

    19. Therapies in amyotrophic lateral sclerosis: options for the near and far future, Robin Lemmens, Ludo Van Den Bosch and Wim Robberecht (Leuven, Belgium)

    20. Symptomatic therapy and palliative aspects of clinical care, Paul H. Gordon and Hiroshi Mitsumoto (New York, NY, USA)

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