Chemical Synthesis by Chain Elongation, Degradation, and Epimerization
- Zoltan Gyorgydeak, Lajos Kossuth University
- Istvan Pelyvas, Research Group of Antibiotics of the Hungarian Academy of Sciences
In a single volume, Monosaccharide Sugars critically summarizes the applied and potentially useful strategies for the synthesis and degradation of monosaccharides by chain-elongation, degradation, and epimerization. These methodologies permit the synthesis of rare or unnatural monosaccharides that are frequently employed as chiral building blocks in natural products synthesis, as well as for producing sugar derivatives labeled with radioactive isotopes. Representative and well-established experimental procedures are provided to illustrate the potential of the synthetic transformation.Degradation of carbohydrates also represents an invaluable tool for the structural elucidation of certain natural products, suchas glycosides, antibiotics, and polysaccharides. When describing the individual methods, unique supplementary collections of the prepared sugar derivatives are shown in tabular form. This compendium will eliminate tedious literature searches for those engaged in research and teaching on the chemistry and biochemistry of saccharides and other natural products, and also for those working on the medicinal and metabolic investigation of related substances of biological importance.
Chemists working in all fields of synthetic organic chemistry, biochemists interested in carbohydrate chemistry and saccharide metabolism, chemists researching isotopically labeled compounds, and medicinal chemists concerned with drug development--in general, those interested in natural products research. Also, graduate and postgraduate students in chemistry, biochemistry, and medicinal chemistry. Staff members working out laboratory procedures for undergraduate students.