Molecular Sensors and Nanodevices

Principles, Designs and Applications in Biomedical Engineering

With applications ranging from medical diagnostics to environmental monitoring, molecular sensors (also known as biosensors, chemical sensors, or chemosensors), along with emerging nanotechnologies offer not only valuable tools but also unlimited possibilities for engineers and scientists to explore the world. New generation of functional microsystems can be designed to provide a variety of small scale sensing, imaging and manipulation techniques to the fundamental building blocks of materials. This book provides comprehensive coverage of the current and emerging technologies of molecular sensing, explaining the principles of molecular sensor design and assessing the sensor types currently available. Having explained the basic sensor structures and sensing principles, the authors proceed to explain the role of nano/micro fabrication techniques in molecular sensors, including MEMS, BioMEMS, MicroTAS among others. The miniaturization of versatile molecular sensors opens up a new design paradigm and a range of novel biotechnologies, which is illustrated through case studies of groundbreaking applications in the life sciences and elsewhere. As well as the techniques and devices themselves, the authors also cover the critical issues of implantability, biocompatibility and the regulatory framework.
The book is aimed at a broad audience of engineering professionals, life scientists and students working in the multidisciplinary area of biomedical engineering. It explains essential principles of electrical, chemical, optical and mechanical engineering as well as biomedical science, intended for readers with a variety of scientific backgrounds. In addition, it will be valuable for medical professionals and researchers. An online tutorial developed by the authors provides learning reinforcement for students and professionals alike.
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Engineers, life scientists and students working in the multidisciplinary area of biomedical device engineering; medical professionals and researchers.


Book information

  • Published: December 2013
  • ISBN: 978-1-4557-7631-3

Table of Contents

1. Introduction to Molecular Sensors Introduction
1.1 Principles of molecular sensors
1.2 Capture and Recognition elements in molecular sensors
1.3 Transduction mechanism
1.4 Performance of Molecular sensors
1.5 Animals as molecular sensors
1.6 Conclusion    
2. Fundamentals of Nano/Microfabrication and Scale Effect 
2.1. Introduction
2.2. Scale effect in molecular sensors
2.3. Microfabrication basics
2.4. Introduction to MEMS
2.5. Soft Lithography
2.6. â€œTop down “and “bottom up” approaches
3. Microfluidics basics and total analytical systems
3.1. Introduction
3.2. Microfluidics fundamentals
3.3. Microfluidics for molecular sensors
4. Electrical transducers: electrochemical sensors and FET-based molecular sensors
4.1. Introduction
4.2. Electrochemical sensors
4.3. FET-based molecular sensors
4.4. Carbon nanotubes (CNTs) and Graphene based Sensors
5. Optical transducers: optical molecular sensors and optical spectroscopy
5.1. Introduction
5.2. Basic EM theory
5.3. Waveguide based molecular sensors
5.4. Surface Plasmon Resonance (SPR) sensors
5.5. Absorption spectroscopy
5.6. Fluorescence spectroscopy
5.7. Light Scattering

6. Mechanical transducers: cantilevers, acoustic wave sensors and thermal sensors
6.1. Introduction
6.2. Cantilever based molecular sensors
6.3. Acoustic molecular sensors: TSM, SAW, FPW, APM, and tuning forks
6.4. Thermal sensors
7. Implantable sensors
7.1. Introduction
7.2. Sensing in cardiac pacemakers
7.3. Implantable electrodes
7.4. Implantable mechanical sensors
7.5. Drug delivery devices
7.6. Energy harvesting implantable devices
7.7. FDA Regulation of Medical Devices