Molecular Photofitting

Predicting Ancestry and Phenotype Using DNA


  • Tony Frudakis, Ph.D., Chief Scientific Officer, DNAprint genomics, Inc.

In the field of forensics, there is a critical need for genetic tests that can function in a predictive or inferential sense, before suspects have been identified, and/or for crimes for which DNA evidence exists but eye-witnesses do not. Molecular Photofitting fills this need by describing the process of generating a physical description of an individual from the analysis of his or her DNA. The molecular photofitting process has been used to assist with the identification of remains and to guide criminal investigations toward certain individuals within the sphere of prior suspects. Molecular Photofitting provides an accessible roadmap for both the forensic scientist hoping to make use of the new tests becoming available, and for the human genetic researcher working to discover the panels of markers that comprise these tests. By implementing population structure as a practical forensics and clinical genomics tool, Molecular Photofitting serves to redefine the way science and history look at ancestry and genetics, and shows how these tools can be used to maximize the efficacy of our criminal justice system.
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Geneticists, biologists, DNA researchers, forensic and physical anthropologists, practicing forensic scientists, crime laboratory personnel, crime scene personnel, Forensic consultants (generalists). Forensic professionals at the FBI, NIST, and other relevant government organizations.


Book information

  • Published: September 2007
  • ISBN: 978-0-12-088492-6

Table of Contents

Chapter 1. Forensic DNA Analysis: from Modest Beginnings to Molecular Photofitting, Genics, Genetics, Genomics and the Pertinent Population Genetics Principles Chapter 2. Ancestry and Admixture Chapter 3. Biogeographical Ancestry Admixture Estimation - Theoretical Considerations Chapter 4. Biogeographical Ancestry Admixture Estimation - Practicality and ApplicationChapter 5. Characterizing Admixture PanelsChapter 6. Apportionment of Autosomal Diversity with Continental MarkersChapter 7. Apportionment of Autosomal Diversity with Sub-Continental Markers Chapter 8. Indirect Methods for Phenotype InferenceChapter 9. Direct Method of Phenotype Inference Chapter 10. The First Case Studies of Molecular Photofitting Chapter 11. The Politics and Ethics of Admixture Analysis and Molecular Photofitting