The Molecular Basis of Human DiseaseEdited by
- William Coleman
- Gregory Tsongalis
Molecular Pathology will be the first textbook for introductory pathology courses in Ph.D. and medical school programs that fully incorporates molecular coverage. Since the mapping of the human genome most biomedical fields have migrated to more molecular approaches to the science. The same is true for pathology however the textbooks have not yet caught up with this trend. This will be the first introductory pathology textbook that truly integrates the molecular mechanisms of human disease.
Medical students, pathology graduate students, biomedical graduate students, and some allied health students.
Hardbound, 664 Pages
Published: February 2009
Imprint: Academic Press
"The editors of Molecular Pathology have produced a comprehensive compendium of the state-of-the-art in molecular pathogenesis, an impressive accomplishment given the diverse cells and organ systems involved in human disease. An established cadre of experts has contributed to this first, well-designed edition. As a result, essential topics ranging from cell injury/death, the molecular basis of cardiovascular diseases and disorders of the nervous system, and modern molecular diagnostics are amply addressed. In a rapidly emerging discipline, it is challenging to capture the details that define the field. Molecular Pathology has accomplished this goal in an outstanding manner and will serve as an excellent resource for those already established in clinical care and biomedical research, for those who seek to maintain competency in molecular pathology, as well as for all students involved in interdisciplinary studies related to human disease or modern clinical investigations." --Linda M. McManus, PhD, Professor, University of Texas Health Science Center at San Antonio "The focus of Molecular Pathology is genetic and molecular but it has been written to enhance the work of an active pathologist, clearly describing the basics as well as providing ample sampling of the molecular complexities of disease. Gladly the editors did not assemble an exhaustive compendium of facts and details that would inevitably become obsolete in short order. Instead, the contributors concentrated on clarity of explanation supported by selected examples so that the reader may grasp the fundamentals better. In fact, this may be one medical textbook that can be read cover-to-cover without being lost in details. The figures are clear, helpful, and plentiful which is important when dealing with so many complex technologies and concepts. I highly recommend this book." --Edison T. Liu, M.D, Executive Director, Genome Institute of Singapore
- PART I: Essential Pathology - Mechanisms of DiseaseChapter 1: Molecular Mechanisms of Cell DeathJohn J. Lemasters, M.D., Ph.D., Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SCChapter 2: Acute and Chronic InflammationVladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D., Department of Pathology, University of Michigan, Ann Arbor, MIChapter 3: Infection and Host ResponseSheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D., Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CTChapter 4: NeoplasiaWilliam B. Coleman, Ph.D., and Tara Rubinas, M.D., Department of Pathology and Laboratory Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NCPART II: Concepts in Molecular Biology and GeneticsChapter 5: Basic Concepts in Human Molecular GeneticsW. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C., Molecular Genetics Laboratory, Mayo Clinic, Rochester, MNChapter 6: The Human Genome: Implications for the Understanding of Human DiseaseAshley Rivenbark, M.D., Department of Pathology and Laboratory Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NCChapter 7: The Human Transcriptome: Implications for the Understanding of Human DiseaseReinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D., Laboratory of Molecular Tumor Pathology, Institute of Pathology, Charite-Universitatsmedizin Berlin, Berlin, GermanyChapter 8: The Human Epigenome: Implications for the Understanding of Human DiseaseManel Esteller, Ph.D. and Maria Berdasco, Ph.D., Cancer Epigenetics Laboratory, Spanish National Cancer Centre, Madrid, SpainChapter 9: The Human Proteome: Implications for the Understanding of Human DiseaseLance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin, The Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VAChapter 10: Integrative Systems Biology: Implications for the Understanding of Human DiseaseM. Michael Barmada, Ph.D. and David C. Whitcomb, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PAPART III: Principles and Practice of Molecular PathologyChapter 11: Pathology: The Clinical Description of Human DiseaseWilliam K. Funkhouser, M.D., Ph.D., Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NCChapter 12: Molecular Pathogenesis: The Biological Basis of Human DiseaseWilliam B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D., Department of Pathology and Laboratory Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, and Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Dartmouth University, Lebanon, NHChapter 13: Integration of Molecular and Cellular PathogenesisJason H. Moore, Ph.D., and C. Harker Rhodes, M.D., Computational Genetics Laboratory, Departments of Genetics and Pathology, Cotton Norris Cancer Center, Dartmouth-Hitchcock Medical Center, Dartmouth University, Lebanon, NHPART IV: Molecular Pathology of Human DiseaseChapter 14: Molecular Basis of Cardiovascular DiseaseAvrum I. Gotlieb, M.D.C.M. and Amber Chang Liu, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, CanadaChapter 15: Molecular Basis of Hemostatic and Thrombotic DiseasesNigel S. Key, M.D., and Alice Ma, M.D., Departments of Medicine and Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NCChapter 16: Molecular Basis of Lymphoid and Myeloid DiseasesDong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D., Department of Molecular and Experimental Medicine, Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, CAChapter 17: Molecular Basis of Diseases of ImmunityDavid O. Beenhouwer, Ph.D., Division of Infectious Diseases, Veterans Affairs Greater Los Angeles Healthcare System, Department of Medicine, David Geffen School of Medicine, Department of Microbiology, Immunology and Molecular Genetics and the Molecular Biology Institute, University of California, Los Angeles, CaliforniaChapter 18: Molecular Basis of Pulmonary DiseaseDani S. Zander, M.D., and Carol Farver, M.D., Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, and Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, OHChapter 19: Molecular Basis of Diseases of the Gastrointestinal TractAntonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D., Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia PAChapter 20: Molecular Basis of Liver DiseaseSatdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D., Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PAChapter 21: Molecular Basis of Diseases of the Exocrine PancreasMarkus M. Lerch, M.D., Department of Gastroenterology, Endocrinology and Nutrition, Ernst-Moritz-Arndt-University, Greifswald, GermanyChapter 22: Molecular Basis of Diseases of the Endocrine SystemMalcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D., Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DCChapter 23: Molecular Basis of Gynecologic Diseases Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D., Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Womenâs Hospital, Harvard Medical School, Dana-Farber Harvard Cancer Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MAChapter 24: Molecular Basis of Prostate DiseaseWilliam G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D., Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MDChapter 25: Molecular Basis of Breast DiseaseChristos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe Bedard, Translational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, BelgiumChapter 26: Molecular Basis of Skin DiseaseJohn A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D., Genetic Skin Disease Group, St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College and St. Thomasâ School of Medicine, London, UKChapter 27: Molecular Basis of Diseases of the Nervous SystemJoshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D., Division of Neuropathology, Department of Pathology, University of Washington, Seattle, WAPART V: Practice of Molecular Medicine Chapter 28: Molecular Diagnosis of Human DiseaseGrant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D., Department of Pathology, University of Virginia Health System, Charlottesville, VAChapter 29: Molecular Assessment of Human Disease in the Clinical LaboratoryGregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D., Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Dartmouth University, Lebanon, NHChapter 30: Pharmacogenomics and Personalized Medicine in the Treatment of Human DiseaseGregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D., Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Dartmouth University, Lebanon, NH