Molecular Neurology


  • Stephen Waxman, Yale University School of Medicine, CT, USA

Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. This book highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology.
View full description


Neuroscientists, molecular biologists, pharmacologists, neurologists, neurology residents, and clinical researchers.


Book information

  • Published: July 2007
  • ISBN: 978-0-12-369509-3

Table of Contents

Molecular NeurologyEdited by Stephen G. WaxmanTable of ContentsPREFACE – Stephen G. WaxmanChapter 1Genetics as a Tool in NeurologyDennis R. Johnson, Fuki M. HisamaChapter 2Neurology and Genomic MedicineJeffery VanceChapter 3Mitochondrial Function and Dysfunction in the Nervous SystemNeggy Rismanchi and Craig BlackstoneChapter 4Neuronal Channels and ReceptorsAlan L. GoldinChapter 5Protein Misfolding, Chaperone Networks, and the Heat Shock Response in the Nervous SystemCindy Voisine, Kai Orton, and Richard I. MorimotoChapter 6Metabolic Biopsy of the BrainOgnen A. C. PetroffChapter 7Gene therapy approaches in neurologyEdward A. Burton, Joseph C. Glorioso, David J. FinkChapter 8Programmed Cell Death and its Role in Neurological DiseaseD. E. Bredesen, R. V. Rao and P. Mehlen1Chapter 9Developmental Neurology: A Molecular PerspectiveJuan M. PascualChapter 10Metabolic Diseases of the Nervous SystemJuan M. PascualChapter 11Genetic Disorders of Neuromuscular DevelopmentJuan M. PascualChapter 12Molecular Mechanisms of Ischemic Brain Disease Thomas M. Hemmen, Justin A. ZivinChapter 13Hemorrhagic Brain DiseaseMichael L. DiLuna, Kaya Bilguvar, Gamze Tanriover, Murat GunelChapter 14The Dawn of Molecular and Cellular Therapies for Traumatic Spinal Cord InjuryNoam Y. Harel, Yvonne S. Yang, Stephen M. Strittmatter, Jeffery D. Kocsis, and Stephen G. WaxmanChapter 15Parkinson’s Disease: Molecular Insights Ted M. Dawson, Josesph M. Savitt, Valina L. DawsonChapter 16The molecular basis of Alzheimer’s diseaseMartin Ingelsson, Bradley T. HymanChapter 17Polyglutamine Disorders including Huntington’s DiseaseSokol V. Todi, Aislinn J. Williams, Henry L. PaulsonChapter 18Friedreich’s Ataxia and Related RNA Loss-Of-Function DisordersMasimo PandolfoChapter 19 DYT1, a Primary Torsion Dystonia Susan B. Bressman, Laurie OzeliusChapter 20Motor Neuron Disease: Amyotrophic Lateral SclerosisNicholas J. Maragakis and Jeffrey D. RothsteinChapter 21Genetic Disorders of the Autonomic Nervous SystemStephen J. PeroutkaChapter 22Multiple sclerosis as a neurodegenerative diseaseStephen G. WaxmanChapter 23Acquired Epilepsy: Cellular and Molecular MechanismsChristopher B. Ransom and Hal Blumenfeld Chapter 24Disorders of Excitation and Transmission: Genetic Epilepsies Ingo Helbig, Ingrid E. Scheffer and Samuel F. BerkovicChapter 25Hyperekplexia (startle disease / stiff baby syndrome): Molecular pathology of the glycine receptor complex Cord-Michael BeckerChapter 26Tourette’s SyndromeJames F. Leckman, Michael H. BlochChapter 27Disorders of Sleep and Circadian RhythmsSebastiaan Overeem, Gert Jan Lammers, Mehdi TaftiChapter 28Chronic pain as a molecular disorderJohn N Wood and Stephen G WaxmanChapter 29Migraine as a cerebral ionopathy with impaired central sensory processingMichel D Ferrari, Arn M.J.M. van den Maagdenberg, Rune R. Frants, and Peter J. GoadsbyChapter 30Dysmyelinating and Demyelinating Disorders of the PNS, or Inherited NeuropathiesJohn A. KamholzChapter 31Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple SclerosisAlexander Flugel, Hartmut WekerleChapter 32Molecular Neurology: Autoimmune disorders of the neuromuscular junction and motor nerve terminalAngela VincentChapter 33Paraneoplastic Neurologic SyndromesJosep DalmauChapter 34Mitochondrial DisordersSalvator DiMauro, Eric A. SchonChapter 35Molecular Neurology of HIV-1 Infection and AIDsMarkus Kaul, Stuart A. Lipton