Molecular Diversity and Combinatorial Chemistry

Principles and Applications


  • Michael Pirrung, Levine Science Research Center, Duke University, Durham, USA

The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact. Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity and function. It emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide to the conceptual framework of the field. The textbook includes exercises and worked problems which can provide more independent learning experiences and can also be used by an instructor leading a class on this topic. This volume has been written with the advanced undergraduate and graduate student in mind.
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For undergraduate and post gradate students, instructors and lecturers in the field of combinatorial chemistry.


Book information

  • Published: September 2004
  • Imprint: ELSEVIER
  • ISBN: 978-0-08-044532-8


"This book is ideal for an advanced student or any chemist who, not being directly involved in combinatorial chemistry, wishes to get a general idea about its principles and applications. In particular, I recommend this book to all academic teachers that give a course (at master or Ph.D. level) on combinatorial chemistry and to their students. I will certainly use it myself as a guidance for my own course on the subject."
Prof. Luca Banfi, University of Genova, MOLECULAR DIVERSITY, 2005

Table of Contents

Nature: The Original Combinatorial Chemist Biopolymers constitute natural libraries
Selection and evolution
The expression of genetic information
Combinatorial assembly of antibody genes
Molecular solutions to combinatorial problems Synthetic Peptide LibrariesSolid-phase peptide synthesis
Peptides on pins
Other iterative deconvolution strategies
Examples of split/couple/mix peptide libraries
Positional scanning
Epilogue Supports, Linkers, and Reagents for Peptide SynthesisPolystyrenes
PEG-grafted supports
Coupling strategies Supports and Linkers for Small Molecule SynthesisNew resins and linkers
Ring-forming cleavage
Loading Encoded Combinatorial ChemistryDirected Sorting Unnatural Oligomers for Library Synthesis Peptoids
Peptidyl phosphonates
Oligoureas Analytical Methods for Solid-phase Synthesis Product identification
Gel-phase NMR
High-resolution magic angle spinning NMR
On-bead infrared spectroscopy
Mass spectrometry
Non-spectroscopic methods Supported Solution-phase Synthesis Polyethylene glycols
Fluorous synthesis Solution-phase Parallel Synthesis Scavenging resins
Ion-exchange resins
Supported reagents
Fluorous reagents
Solid-phase extraction
Gas-phase separation Multi-component Reactions Chemical Informatics, Diversity, and Library Design Strategies
Representative flowchart for a library design
Lipinski's Rules Nucleic Acid Microarrays Combinatorial Materials Chemistry Combinatorial Catalyst Discovery Peptides on Phage Applications of phage display Nucleic Acid Selection Complex Combinatorial and Solid-phase Synthesis Epibatidine
The Big Picture