Molecular Diversity and Combinatorial Chemistry book cover

Molecular Diversity and Combinatorial Chemistry

Principles and Applications

The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact.

Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity and function. It emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide to the conceptual framework of the field.

The textbook includes exercises and worked problems which can provide more independent learning experiences and can also be used by an instructor leading a class on this topic.

This volume has been written with the advanced undergraduate and graduate student in mind.

Audience
Advanced undergraduate students or graduate students

Hardbound, 188 Pages

Published: September 2004

Imprint: Elsevier

ISBN: 978-0-08-044493-2

Contents

  • Nature: The Original Combinatorial Chemist Biopolymers constitute natural libraries
    Selection and evolution
    The expression of genetic information
    Combinatorial assembly of antibody genes
    Molecular solutions to combinatorial problems
    Synthetic Peptide LibrariesSolid-phase peptide synthesis
    Peptides on pins
    Other iterative deconvolution strategies
    Examples of split/couple/mix peptide libraries
    Positional scanning
    Epilogue
    Supports, Linkers, and Reagents for Peptide SynthesisPolystyrenes
    PEG-grafted supports
    Coupling strategies
    Supports and Linkers for Small Molecule Synthesis New resins and linkers
    Ring-forming cleavage
    Loading
    Encoded Combinatorial ChemistryDirected Sorting Unnatural Oligomers for Library Synthesis Peptoids
    Azatides
    Peptidyl phosphonates
    Oligoureas
    Analytical Methods for Solid-phase Synthesis Product identification
    Gel-phase NMR
    High-resolution magic angle spinning NMR
    On-bead infrared spectroscopy
    Mass spectrometry
    Non-spectroscopic methods
    Supported Solution-phase Synthesis Polyethylene glycols
    Dendrimers
    Fluorous synthesis
    Solution-phase Parallel Synthesis Scavenging resins
    Ion-exchange resins
    Supported reagents
    Fluorous reagents
    Solid-phase extraction
    Gas-phase separation
    Multi-component Reactions Chemical Informatics, Diversity, and Library Design Strategies
    Representative flowchart for a library design
    Lipinski's Rules
    Nucleic Acid Microarrays Combinatorial Materials Chemistry Combinatorial Catalyst Discovery Peptides on Phage Applications of phage display
    Nucleic Acid Selection Complex Combinatorial and Solid-phase Synthesis Epibatidine
    Mappicine
    Dysidiolide
    The Big Picture

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