Molecular Diversity and Combinatorial Chemistry

Principles and Applications

By

  • Michael Pirrung, Levine Science Research Center, Duke University, Durham, USA

The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact.

Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity and function. It emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide to the conceptual framework of the field.

The textbook includes exercises and worked problems which can provide more independent learning experiences and can also be used by an instructor leading a class on this topic.

This volume has been written with the advanced undergraduate and graduate student in mind.

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Audience

Advanced undergraduate students or graduate students

 

Book information

  • Published: September 2004
  • Imprint: ELSEVIER
  • ISBN: 978-0-08-044493-2


Table of Contents

Nature: The Original Combinatorial Chemist Biopolymers constitute natural libraries
Selection and evolution
The expression of genetic information
Combinatorial assembly of antibody genes
Molecular solutions to combinatorial problems
Synthetic Peptide LibrariesSolid-phase peptide synthesis
Peptides on pins
Other iterative deconvolution strategies
Examples of split/couple/mix peptide libraries
Positional scanning
Epilogue
Supports, Linkers, and Reagents for Peptide SynthesisPolystyrenes
PEG-grafted supports
Coupling strategies
Supports and Linkers for Small Molecule Synthesis New resins and linkers
Ring-forming cleavage
Loading
Encoded Combinatorial ChemistryDirected Sorting Unnatural Oligomers for Library Synthesis Peptoids
Azatides
Peptidyl phosphonates
Oligoureas
Analytical Methods for Solid-phase Synthesis Product identification
Gel-phase NMR
High-resolution magic angle spinning NMR
On-bead infrared spectroscopy
Mass spectrometry
Non-spectroscopic methods
Supported Solution-phase Synthesis Polyethylene glycols
Dendrimers
Fluorous synthesis
Solution-phase Parallel Synthesis Scavenging resins
Ion-exchange resins
Supported reagents
Fluorous reagents
Solid-phase extraction
Gas-phase separation
Multi-component Reactions Chemical Informatics, Diversity, and Library Design Strategies
Representative flowchart for a library design
Lipinski's Rules
Nucleic Acid Microarrays Combinatorial Materials Chemistry Combinatorial Catalyst Discovery Peptides on Phage Applications of phage display
Nucleic Acid Selection Complex Combinatorial and Solid-phase Synthesis Epibatidine
Mappicine
Dysidiolide
The Big Picture