Molecular Diagnostics book cover

Molecular Diagnostics

Techniques and Applications for the Clinical Laboratory

Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. This handbook provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting.

Pathologists, laboratory technicians, geneticists, physicians, medical students, and other health care professionals involved in molecular testing.

Hardbound, 736 Pages

Published: December 2009

Imprint: Academic Press

ISBN: 978-0-12-369428-7


  • I. Introduction and Methodology  
    Quantivative PCR: an introduction
    Signal Amplification Methods in Molecular Diagnostics
    The Lab-on-a-Chip Approach for Molecular Diagnostics
    Nucleic Extraction and Amplification
    General Procedures
    II. Quality Assurance, Regulatory, and Ethical Issues  
    Billing and Reimbursement for Molecular Diagnostics
    Molecular Pathology and Infectious Diseases
    Ethical Considerations in Molecular Diagnostics
    Quality Control, Assurance, Identification and Standards
    III. Genetic Disease  
    Molecular Testing for Cystic Fibrosis and CFTR-Related Conditions
    Carrier Testing for Neurogenetic Diseases
    Standards and Recommendations for Molecular Diagnostic Testing for Huntington Disease, the Autosomal Dominant Spinocerebellar Ataxias, and Friedreich Ataxia
    IV. Cancer  
    The Role of Micro-RNAs in Cancer
    Molecular Diagnostics in the Evaluation of Cancer: Modern Concepts and Overview
    Gene Expression Analysis for Tumor Profiling GEA for TP
    Molecular Diagnostics of Hematopoetic Malignancies
    V. Infectious Diseases   
    Hepatic B and C Viruses
    Molecular Diagnosis of Cytomegalovirus
    Molecular Detection of Multiple Respiratory Viruses

    Molecular Methods for Identification and Characterization of Acinetobacter species
    Molecular Detection and Surveillance of Healthcare-Associated Infections
    Molecular Detection Of Group B Streptococcus
    Role of Molecular Techniques in the Epidemiologic Investigation Of Hospital-Acquired Infections
    Human Papilloma Virus and its Role in Cervical Carcinoma
    VI. Specialized Applications of Molecular Testing  
    Molecular HLA Typing Methods Used in Clinical Laboratories
    Identification through DNA analysis in criminal and family relatedness investigations.

    VII. Pharmacogenetics  
    Overview of Pharmacogenomics and Applications for the Modern Clinical Laboratory
    UDP-Glucuronosyltransferase 1A1 and the Glucuronidation in Oncology Applications and Hyperbilirubinemia
    Pharmacogenetics of P-450 Enzymes
    Pharmacogenomics of Thiopurine Methyl Transferase (TPMT): Importance in Monitoring of Mercaptopurine/Azathioprine Therapy


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