Molecular Biology

By

  • David Clark, BA (honors)Christ's College Cambridge, 1973 PhD University of Brsitol (England), 1977, Southern Illinois University, Carbondale, Illinois, USA
  • Nanette Pazdernik, Washington University School of Medicine, St. Louis, Missouri, USA

The last quarter of the 20th century saw major scientific revolutions in genetics and computer technology. The second edition of Molecular Biology, winner of a 2013 Texty Award from the Text and Academic Authors Association, reflects this massive surge in our understanding of the molecular foundations of genetics. In order to understand where these technological advances are heading, there needs to be a basic understanding of how living organisms function at a molecular level. This volume effectively introduces basic concepts followed by more specific applications as the text evolves. With the addition of Cell Press articles, the content is tied to current topics in the scientific community.
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Audience

Undergraduate students taking a course in Molecular Biology; upper-level students studying Cell Biology, Microbiology, Genetics, Biology, Pharmacology, Biotechnology, Biochemistry and Agriculture

 

Book information

  • Published: February 2012
  • Imprint:
  • ISBN: 978-0-12-378594-7

Reviews

"This molecular biology textbook from Clark and Pazdernik is geared toward upper-level undergraduate and beginning graduate students. The book is written with a preference for breadth over depth, beginning with several chapters to cover the basics for students with a non-molecular background in biology and continuing on in survey fashion to the topics of genomics research, RNA and protein function, gene expression, subcellular life-forms, and DNA alteration."--Reference & Research Book News, October 2013
"This book reflects the massive surge in our understanding of the molecular foundations of genetics. In order to understand where these technological advances are heading, there needs to be a basic understanding of how living organisms function at a molecular level. Molecular Biology, 2e, effectively introduces basic concepts followed by more specific applications as the text evolves."--ANTICANCER RESEARCH 33: 745-746 (2013), February 2013
"This comprehensive text gives students and researchers a sound and practical knowledge of molecular biology. Consisting of 28 lucidly written chapters, this book presents basic concepts, recent updates, methodological principles and applications in this central biology discipline. The authors have adopted an interesting pedagogic approach to ensure smooth delivery of the presented information. This involved the use of nicely-designed meaningful illustrations, highlighting key concepts in each chapter, and raising review and conceptual questions. There is also a novel feature of ‘Focus on Relevant Research’ sections relating pertinent research articles to key concepts in the text. These sections illustrate how the development of frontier research in molecular biology is based upon the proper understanding of its prime concepts. This second edition of the text is accompanied by an online study guide, which contains useful material including review questions, and references to relevant articles. I would highly recommend this informative, well-presented book to students and researchers seeking sound and practical updated knowledge in molecular biology."--
Science Progress




Table of Contents

Unit 1: Basic Chemical and Biological Principles

Ch1 Cells and Organisms

Ch2 Basic Genetics

Ch3 DNA, RNA, and Protein

Ch4 Genes, Genomes, and DNA

Ch5 Manipulation of Nucleic Acids

Unit 2: The Genome

Ch6 Polymerase Chain Reaction

Ch7 Cloning Genes for Analysis

Ch8 DNA Sequencing

Ch9 Genomics & Systems Biology

Unit 3: The Central Dogma of Molecular Biology

Ch10 Cell Division and DNA Replication

Ch11 Transcription of Genes

Ch12 Processing of RNA

Ch13 Protein Synthesis

Ch14 Protein Structure & Function

Ch15 Proteomics: Global Analysis of Proteins

Unit 4: Regulating Gene Expression

Ch16 Regulation of Transcription in Prokaryotes

Ch17 Regulation of Transcription in Eukaryotes

Ch18 Regulation at RNA Level

Ch19 Analysis of Gene Expression (Transcriptome)

Unit 5: Subcellular Life Forms

Ch20 Plasmids

Ch21 Viruses

Ch22 Mobile DNA

Unit 6: Changing the DNA Blueprint

Ch23 Mutations and Repair

Ch24 Recombination

Ch25 Bacterial Genetics

Ch26 Molecular Evolution