Molecular Biology of B Cells

Edited by

  • Tasuku Honjo, Kyoto University, Japan
  • Michael Reth, Albert-Ludwigs University Freiburg, Germany
  • Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Germany
  • Frederick Alt, Harvard Medical School, USA
  • Tasuku Honjo, Kyoto University, Japan
  • Michael Neuberger, Medical Research Council Laboratory of Molecular Biology

Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.
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Research level immunologists, molecular biologists and geneticists


Book information

  • Published: February 2003
  • ISBN: 978-0-12-053641-2

Table of Contents

ORGANIZATION, REARRANGEMENT AND TRANSCRIPTION OF IMMUNOGLOBULIN GENESHuman Immunoglobulin heavy chains locusImmunoglobulin heavy chain genes of mouseImmunoglobulin genes of human and mouseImmunoglobulin lambdav (IGL) genes of human and mouseThe Mechanism of V(D) J RecombinationTranscription of Immunoglobulin genesB CELLS AND THEIR DEVELOPMENTEarly B cell development to a mature , antigen-sensitive cell - cellular stages and molecular decisionsAllelic exclusion, Isotypic exclusion and the Developmental Regulation of V(D)J RecombinationThe Development of Human B LymphocytesDevelopment and function of B cell subsetsB CELL DIFFERENTIATION INDUCED BY Ag STIMULATIONStructure and function of B cells antigen receptor complexesRegulation of antigen receptor signaling by the co-receptors, CD19 and CD22The dynamic structure of antibody responsesDynamics of B cell migration to and within secondary lymphoid organsCharacteristics of mucosal B cells with emphasis on the human secretory immune systemThe Cellular Basis of B Cell MemoryImmunoglobulin assembly and secretionFc And Complement Receptors