Molecular Biology of B Cells book cover

Molecular Biology of B Cells

Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.

Audience
Research level immunologists, molecular biologists and geneticists

Hardbound, 600 Pages

Published: February 2003

Imprint: Academic Press

ISBN: 978-0-12-053641-2

Contents

  • ORGANIZATION, REARRANGEMENT AND TRANSCRIPTION OF IMMUNOGLOBULIN GENESHuman Immunoglobulin heavy chains locusImmunoglobulin heavy chain genes of mouseImmunoglobulin genes of human and mouseImmunoglobulin lambdav (IGL) genes of human and mouseThe Mechanism of V(D) J RecombinationTranscription of Immunoglobulin genesB CELLS AND THEIR DEVELOPMENTEarly B cell development to a mature , antigen-sensitive cell - cellular stages and molecular decisionsAllelic exclusion, Isotypic exclusion and the Developmental Regulation of V(D)J RecombinationThe Development of Human B LymphocytesDevelopment and function of B cell subsetsB CELL DIFFERENTIATION INDUCED BY Ag STIMULATIONStructure and function of B cells antigen receptor complexesRegulation of antigen receptor signaling by the co-receptors, CD19 and CD22The dynamic structure of antibody responsesDynamics of B cell migration to and within secondary lymphoid organsCharacteristics of mucosal B cells with emphasis on the human secretory immune systemThe Cellular Basis of B Cell MemoryImmunoglobulin assembly and secretionFc And Complement Receptors

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