Modifications of Nuclear DNA and its Regulatory Proteins book cover

Modifications of Nuclear DNA and its Regulatory Proteins

DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer.

Audience

Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Hardbound, 502 Pages

Published: April 2011

Imprint: Academic Press

ISBN: 978-0-12-387685-0

Reviews

  • PRAISE FOR THE SERIES
    "Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal


Contents

    1. Introduction - Epiphanies in Epigenetics
      Xiaodong Cheng and Robert M. Blumenthal
    2. Section I. EVOLUTION OF DNA METHYLATION

    3. The natural history of eukaryotic DNA methylation systems
      Lakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind
    4. Evolution of histone methyltransferases and demethylases
      L. Aravind
    5. DNA methylation in Drosophila - A critical evaluation
      Veiko Krauss and Gunter Reuter
    6. DNA Methylation in Zebrafish
      Mary G Goll and Marnie E Halpern
    7. Seciton II. MAMMALIAN DNA METHYLTRANSFERASES - STRUCTURE AND FUNCTION

    8. Dnmt1 - structure and function
      Željko M. Svedružić
    9. The DNMT3 family of MAMMALIAN de novo DNA methyltransferases
      Frédéric Chédin
    10. Seciton III. DNA METHYLATION AND DEMETHYLATION

    11. Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factors
      Jafar Sharif & Haruhiko Koseki
    12. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cells
      Shannon R. Morey Kinney and Sriharsa Pradhan
    13. Mechanistic and functional links between histone methylation and DNA methylation
      Taiping Chen
    14. Section IV. DNA METHYLATION IN MEDICINE

    15. RNA mediated silencing mechanisms in mammalian cells
      Anton Wutz
    16. Biological functions of methyl-CpG binding proteins
      Pierre-Antoine Defossez and Irina Stancheva
    17. Section V. DNA METHYLATION IN MEDICINE

    18. Diseases associated with imprinting
      J.F. Wilkins and F. Úbeda
    19. DNA methylation changes in cancer
      Minoru Toyota and Eiichiro Yamamoto
    20. Epigenetic biomarkers
      J. Tost
    21. Distribution of methylation at the single-nucleotide level
      E. Wong

Advertisement

advert image