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Modifications of Nuclear DNA and its Regulatory Proteins

Edited by
  • Xiaodong Cheng, Emory University School of Medicine, Atlanta, GA, USA
  • Robert Blumenthal, The University of Toledo College of Medicine, OH, USA

DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer.

Audience
Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Included in series
Progress in Molecular Biology and Translational Science

Hardbound, 502 Pages

Published: April 2011

Imprint: Academic Press

ISBN: 978-0-12-387685-0

Reviews

  • PRAISE FOR THE SERIES "Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal

Contents

    1. Introduction - Epiphanies in Epigenetics
      Xiaodong Cheng and Robert M. Blumenthal

      2. Section I. EVOLUTION OF DNA METHYLATION

    2. The natural history of eukaryotic DNA methylation systems
      Lakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind
    3. Evolution of histone methyltransferases and demethylases
      L. Aravind
    4. DNA methylation in Drosophila - A critical evaluation
      Veiko Krauss and Gunter Reuter
    5. DNA Methylation in Zebrafish
      Mary G Goll and Marnie E Halpern

      6. Seciton II. MAMMALIAN DNA METHYLTRANSFERASES - STRUCTURE AND FUNCTION

    6. Dnmt1 - structure and function
      Željko M. Svedružic
    7. The DNMT3 family of MAMMALIAN de novo DNA methyltransferases
      Frédéric Chédin

      8. Seciton III. DNA METHYLATION AND DEMETHYLATION

    8. Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factors
      Jafar Sharif & Haruhiko Koseki
    9. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cells
      Shannon R. Morey Kinney and Sriharsa Pradhan
    10. Mechanistic and functional links between histone methylation and DNA methylation
      Taiping Chen

      11. Section IV. DNA METHYLATION IN MEDICINE

    11. RNA mediated silencing mechanisms in mammalian cells
      Anton Wutz
    12. Biological functions of methyl-CpG binding proteins
      Pierre-Antoine Defossez and Irina Stancheva

      13. Section V. DNA METHYLATION IN MEDICINE

    13. Diseases associated with imprinting
      J.F. Wilkins and F. Úbeda
    14. DNA methylation changes in cancer
      Minoru Toyota and Eiichiro Yamamoto
    15. Epigenetic biomarkers
      J. Tost
    16. Distribution of methylation at the single-nucleotide level
      E. Wong

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