Models of Seizures and Epilepsy book cover

Models of Seizures and Epilepsy

An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research.

Neurologists, epileptologists, developmental neuroscientists, medical geneticists, molecular/developmental biologists.

Hardbound, 712 Pages

Published: August 2005

Imprint: Academic Press

ISBN: 978-0-12-088554-1


  • "This book is an invaluable resource for those interested in the details of epilepsy. It will be an excellent resource for all neurologists and neurosurgeons involved in research or clinical treatment for the disease." --NEUROSURGERY QUATERLY (Mar-May 2006) "5 Stars - This is a superb and current compendium of selected models of epilepsy and their utility in investigating the various mechanisms and manifestations of epilepsy. ...This book should be on the shelf as a resource for all investigators of the mechanisms of epilepsy whether they utilize cells, slices, mice, humans, or machines. It fills an important void in the review literature that has not been comprehensively addressed for some time." --Gregory Kent Bergery, Johns Hopkins University School of Medicine, in DOODY'S (May 2006)


  • Contributing Authors



    1. What Should Be Modeled?

    A. In Vitro Preparations

    2. Single Nerve Cells Acutely Dissociated from Animal and Human Brains for Studies of Epilepsy

    3. Cell Culture Models for Studying Epilepsy

    4. An Overview of In Vitro Seizure Models in Acute and Organotypic Slices

    5. The Use of Brain Slice Cultures for the Study of Epilepsy

    6. Hippocampal Slices: Designing and Interpreting Studies in Epilepsy Research

    7. Thalamic, Thalamocortical and Corticocortical Models of Epilepsy with an Emphasis on Absence Seizures

    8. Studying Epilepsy in the Human Brain In Vitro

    9. In Vitro Isolated Guinea Pig Brain

    B. Induced Seizures in Intact Animals

    10. Pharmacologic Models of Generalized Absence Seizures in Rodents

    11. Models of Chemically-Induced Acute Seizures

    12. Electrical Stimulation-Induced Models of Seizures

    13. Alcohol Withdrawal Seizures

    14. Alumina Gel Injection Models of Epilepsy in Monkeys

    C. Genetic Models

    15. Modeling Epilepsy and Seizures in Developing Zebrafish Larvae

    16. Transgenic and Gene Replacement Models of Epilepsy: Targeting Ion Channel and Neurotransmission Pathways in Mice

    17. Spontaneous Epileptic Mutations in the Mouse

    18. Genetic Models of Absence Epilepsy in the Rat

    19. Models with Spontaneous Seizures and Developmental Disruption of Genetic Etiology

    20. Mammalian Models of Genetic Epilepsy Characterized by Sensory-Evoked Seizures and Generalized Seizure Susceptibility

    21. Inherited Epilepsy in Mongolian Gerbils

    D. Acquired Focal Models

    22. The Cortical Freeze Lesion Model

    23. MAM and Other “Lesion” Models of Developmental Epilepsy

    24. In Utero Irradiation as a Model of Cortical Dysplasia

    25. Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in the Neonatal Period

    26. Complex Febrile Seizures-An Experimental Model in Immature Rodents

    27. Repetitive Seizures in the Immature Brain

    28. The Kindling Phenomenon

    29. Kindling Kittens and Cats

    30. Electrical Kindling in Developing Rats

    31. Chemical Kindling

    32. Kindling, Spontaneous Seizures, and the Consequences of Epilepsy: More than a Model

    33. Tetanus Toxin Model of Focal Epilepsy

    34. Kainate-Induced Status Epilepticus: a Chronic Model of Acquired Epilepsy

    35. The Pilocarpine Model of Seizures

    36. Status Epilepticus: Electrical Stimulation Models

    37. Posttraumatic Epilepsy Induced by Lateral Fluid-Percussion Brain Injury in Rats

    38. Chronic Partial Cortical Isolation

    39. Head Trauma: Hemorrhage-Iron Deposition

    40. Stroke

    41. Models Available for Infection-Induced Seizures

    42. Brain Tumour and Epilepsy: A New Neurophysiologic and Neuropathologic Ex Vivo In Vitro Model

    43. An Animal Model of Rasmussen’s Encephalitis

    E. Models Used for Pharmacological Assessment

    44. Therapeutic Assays for the Identification and Characterization of Antiepileptic and Antiepileptogenic Drugs

    45. Animal Models of Drug-Refractory Epilepsy

    F. Technical Approaches for Model Characterization

    46. Monitoring for Seizures in Rodents

    47. Imaging Approaches in Small Animal Models

    48. Behavioral Characterization of Seizures in Rats

    49. Behavioral and Cognitive Testing Procedures in Animal Models of Epilepsy

    50. Morphologic Approaches to the Characterization of Epilepsy Models

    G. Important Questions

    51. Animal Model Development Based on the Human Epilepsies: Which Causes and Syndromes Should Be Modeled?

    52. What Good are Animal Models



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