Models of Protection Against HIV/SIV
Avoiding AIDS in humans and monkeys
- Gianfranco Pancino, INSERM and Institut Pasteur – Regulation of Retroviral Infections Unit, Paris, France
- Guido Silvestri, Emory University & Yerkes National Primate Research Center, Atlanta, GA, USA
- Keith Fowke, University of Manitoba, Winnipeg, Manitoba Canada
Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. BarrÃ©-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer.
This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike.
AudienceThe primary audience for this work is HIV/AIDS physicians, researchers and policy makers in academia, industry and government, as well as, medical and graduate students looking to further their understanding of HIV/AIDS vaccine efforts.
- Published: December 2011
- Imprint: ACADEMIC PRESS
- ISBN: 978-0-12-387715-4
Table of Contents
Simian models of non-pathogenic SIV infection
- Natural SIV infection: virological aspects
- Natural SIV infection: immunological aspects
- Implications for therapy
HIV-1-exposed seronegative individuals
- Are some people protected against HIV infection?
- The genital mucosa, the front lines in the defense against HIV
- Host genetics and resistance to HIV-1 infection
- The immune system and resisting HIV infection
- Definition, natural history and heterogeneity of HIV-controllers
- Residual viremia and viral reservoirs in elite controllers
- Immune responses associated to viral control
- Immune mechanisms of viral control in HIV-2 infection
Genetic basis of protection against HIV
- Genetic associations with resistance to HIV-1 infection, viral control and protection against disease