Modeling for Preparative Chromatography

By

  • Georges Guiochon, Department of Chemistry, University of Tennessee, Knoxville, TN, USA
  • Bingchang Lin, Anshan Institute of Iron and Steel, Anshan, Lianing, People's Republic of China

Nonlinear chromatography is a field that borders both chemical engineering and physical chemistry. In turn, the theory of nonlinear chromatography is the foundation of preparative chromatography, a separation process that has lately become of considerable interest in the pharmaceutical industry. Only chromatography is sufficiently flexible and powerful to satisfy the practical requirements encountered in most difficult separations of pharmaceuticals and pharmaceutical intermediates. Since "nonlinear" behaviour is strictly a mathematical concept, it is difficult to leave mathematics out of any fundamental study of nonlinear chromatography. Therefore, this book will describe the different mathematical models of chromatography, examine the assumptions on which they are based, consider their properties, and discuss their solutions. All this will be done from a mathematical analysis point of view, paying considerable attention to the influence of nonlinear behavior on the results.
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Audience

Graduate students in analytical and physical chemistry and in chemical engineering. Separation scientists and engineers in pharmaceutical companies and in manufacturers of fine chemicals.

 

Book information

  • Published: May 2003
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-044983-5


Table of Contents

CHAPTER I. INTRODUCTIONCHAPTER II. PHYSICO-CHEMICAL BASIS OF CHROMATOGRAPHYCHAPTER III. MATHEMATICAL BASIS OF CHROMATOGRAPHYCHAPTER IV. THE PROFILES OF SINGLE COMPONENT BANDSIN LINEAR NONIDEAL CHROMATOGRAPHYCHAPTER V. SINGLE COMPONENT, IDEAL, NONLINEAR CHROMATOGRAPHYCHAPTER VI. IDEAL NONLINEAR REACTION CHROMATOGRAPHY CHAPTER VII. THE PROFILES OF SINGLE-COMPONENT BANDSIN NONLINEAR NONIDEAL CHROMATOGRAPHYCHAPTER VIII. TWO-COMPONENT IDEAL NONLINEAR CHROMATOGRAPHYCHAPTER IX. NUMERICAL ANALYSIS OF CHROMATOGRAPHYPROBLEMS