Mims' Pathogenesis of Infectious Disease

Infectious diseases are the leading cause of death worldwide, and are increasing in almost every nation, including the United States; they ranked third among the leading causes of death in the U.S. in 1992. Infectious diseases can be caused by bacteria, parasites, viruses, and other microbes such as fungus. They are part of everyday life, and range in severity from strep throat to AIDS. Mims' Pathogenesis of Infectious Disease has been the landmark book in the field. This revised edition provides an up-to-date picture of the global burden of infectious disease. It explains principles clearly and completely, using examples from various infections. It covers the mechanisms for spread of disease, immune response, and recovery, and is ideal as a course text for graduate and undergraduate students.

Undergraduate and graduate students in microbiology and immunology, medical students, and others new to the field of microbiology and infectious diseases.

Paperback, 464 Pages

Published: September 2000

Imprint: Academic Press

ISBN: 978-0-12-498265-9


  • "This is an outstanding book of high scholarship of much interest to immunologists, microbiologists, pathologists and all those concerned with infectious diseases."
    Reviews of previous Editions:, --MOLECULAR MEDICINE TODAY

    "A splendidly imaginative book which will become a trusty companion for many of us."
    "A short but comprehensive description of the mechanisms of infectious disease in an eminently readable form suitable for undergraduates in medicine, veterinary medicine and microbiology. An excellent book which should be read by teachers, students and research workers."
    "In bringing this material together clearly in one short thoughtful volume, Professor Mims offers the student a chance to acquire a sound appreciation of the infectious process."
    "In remains excellent value for money and will I am sure long continue to be a standard text."
    "Clear, well-written text including tables, and impressive schematic drawings."


  • Preface to the Fifth EditionPreface to the Fourth EditionPreface to the Third EditionPreface to the Second EditionPreface to the First Edition1 General Principles References2 Attachment to and Entry of Microorganisms into the Body Introduction Adhesion/Entry: Some General Considerations The Skin Respiratory Tract Gastro-Intestinal Tract Oropharynx Urinogenital Tract Conjunctiva The Normal Microbial Flora Exit of Microorganisms From the Body References3 Events Occurring Immediately After the Entry of the Microorganism Growth in Epithelial Cells Intracellular Microorganisms and Spread through the Body Subepithelial Invasion Nutritional Requirements of Invading Microbes References4 The Encounter with the Phagocytic Cell and the Microbe's Answers Cell Biology of Phagocytosis Phagocytosis in Polymorphonuclear Leucocytes Phagocytosis in Macrophages Microbial Strategy in Relation to Phagocytes Growth in the Phagocytic Cell Killing the Phagocyte Entry into the Host Cell Other than by Phagocytosis Consequences of Defects in the Phagocytic Cell Summary References5 The Spread of Microbes through the Body Direct Spread Microbial Factors Promoting Spread Spread via Lymphatics Spread via the Blood Spread via Other Pathways References6 The Immune Response to Infection Antibody Response T-Cell-Mediated Immune Response Natural Killer Cells Macrophages, Polymorphs and Mast Cells Complement and Related Defense Molecules Conclusions Concerning the Immune Response to Microorganisms References7 Microbial Strategies in Relation to the Immune Response Infection Completed before the Adaptive Immune Response Intervenes Induction of Immunological Tolerance Immunosuppression Absence of a Suitable Target for the Immune Response Microbial Presence in Bodily Sites Inaccessible to the Immune Response Induction of Inappropriate Antibody and T-Cell Responses Antibodies Mopped Up by Soluble Microbial Antigens Local Interference with Immune Forces Reduced Interferon Induction or Responsiveness Antigenic Variation Microorganisms that Avoid Induction of an Immune Response References8 Mechanisms of Cell and Tissue Damage Infection with no Cell or Tissue Damage Direct Damage by Microorganisms Microbial Toxins Indirect Damage via Inflammation Indirect Damage via the Immune Response (Immunopathology) Other Indirect Mechanisms of Damage Diarrhoea References9 Recovery from Infection Immunological Factors in Recovery Inflammation Complement Interferons Multimechanistic Recovery: An Example Temperature Tissue Repair Resistance to Re-Infection References10 Failure to Eliminate Microbe Latency Persistent Infection with Shedding Epidemiological Significance of Persistent Infection with Shedding Persistent Infection without Shedding Significance for the Individual of Persistent Infections Conclusions References11 Host and Microbial Factors Influencing Susceptibility Genetic Factors in the Microorganism Genetic Factors in the Host Hormonal Factors and Stress Other Factors References12 Vaccines and How they Work Introduction General Principles Complications and Side Effects of Vaccines The Development of New Vaccines ReferencesAppendixConclusions ReferencesGlossaryIndex


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