Mims

Mims' Pathogenesis of Infectious Disease

Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery.

Audience
Undergraduate and graduate students in microbiology and immunology, medical students, and others new to the field of microbiology and infectious diseases.

Paperback, 464 Pages

Published: September 2000

Imprint: Academic Press

ISBN: 978-0-12-498264-2

Reviews

  • Praise for the previous editions: "This is an outstanding book of high scholarship of much interest to immunologists, microbiologists, pathologists and all those concerned with infectious diseases." -Molecular Medicine Today "A splendidly imaginative book which will become a trusty companion for many of us." - The Lancet "An excellent book which should be read by teachers, students, and research workers." - New Scientist

Contents


  • Preface to the Fifth Edition

    Preface to the Fourth Edition

    Preface to the Third Edition

    Preface to the Second Edition

    Preface to the First Edition

    1 General Principles

    References

    2 Attachment to and Entry of Microorganisms into the Body

    Introduction

    Adhesion/Entry: Some General Considerations

    The Skin

    Respiratory Tract

    Gastro-Intestinal Tract

    Oropharynx

    Urinogenital Tract

    Conjunctiva

    The Normal Microbial Flora

    Exit of Microorganisms From the Body

    References

    3 Events Occurring Immediately After the Entry of the Microorganism

    Growth in Epithelial Cells

    Intracellular Microorganisms and Spread through the Body

    Subepithelial Invasion

    Nutritional Requirements of Invading Microbes

    References

    4 The Encounter with the Phagocytic Cell and the Microbe's Answers

    Cell Biology of Phagocytosis

    Phagocytosis in Polymorphonuclear Leucocytes

    Phagocytosis in Macrophages

    Microbial Strategy in Relation to Phagocytes

    Growth in the Phagocytic Cell

    Killing the Phagocyte

    Entry into the Host Cell Other than by Phagocytosis

    Consequences of Defects in the Phagocytic Cell

    Summary

    References

    5 The Spread of Microbes through the Body

    Direct Spread

    Microbial Factors Promoting Spread

    Spread via Lymphatics

    Spread via the Blood

    Spread via Other Pathways

    References

    6 The Immune Response to Infection

    Antibody Response

    T-Cell-Mediated Immune Response

    Natural Killer Cells

    Macrophages, Polymorphs and Mast Cells

    Complement and Related Defense Molecules

    Conclusions Concerning the Immune Response to Microorganisms

    References

    7 Microbial Strategies in Relation to the Immune Response

    Infection Completed before the Adaptive Immune Response Intervenes

    Induction of Immunological Tolerance

    Immunosuppression

    Absence of a Suitable Target for the Immune Response

    Microbial Presence in Bodily Sites Inaccessible to the Immune Response

    Induction of Inappropriate Antibody and T-Cell Responses

    Antibodies Mopped Up by Soluble Microbial Antigens

    Local Interference with Immune Forces

    Reduced Interferon Induction or Responsiveness

    Antigenic Variation

    Microorganisms that Avoid Induction of an Immune Response

    References

    8 Mechanisms of Cell and Tissue Damage

    Infection with no Cell or Tissue Damage

    Direct Damage by Microorganisms

    Microbial Toxins

    Indirect Damage via Inflammation

    Indirect Damage via the Immune Response (Immunopathology)

    Other Indirect Mechanisms of Damage

    Diarrhoea

    References

    9 Recovery from Infection

    Immunological Factors in Recovery

    Inflammation

    Complement

    Interferons

    Multimechanistic Recovery: An Example

    Temperature

    Tissue Repair

    Resistance to Re-Infection

    References

    10 Failure to Eliminate Microbe

    Latency

    Persistent Infection with Shedding

    Epidemiological Significance of Persistent Infection with Shedding

    Persistent Infection without Shedding

    Significance for the Individual of Persistent Infections

    Conclusions

    References

    11 Host and Microbial Factors Influencing

    Susceptibility

    Genetic Factors in the Microorganism

    Genetic Factors in the Host

    Hormonal Factors and Stress

    Other Factors

    References

    12 Vaccines and How they Work

    Introduction

    General Principles

    Complications and Side Effects of Vaccines

    The Development of New Vaccines

    References

    Appendix

    Conclusions

    References

    Glossary

    Index

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