Microbial Synthetic Biology

Edited by

  • Colin Harwood, Newcastle University, UK
  • Anil Wipat, University of Newcastle upon Tyne

The 40th volume of Methods in Microbiology focuses on microbial synthetic biology.

Synthetic biology is a rapidly growing discipline that builds on well-established principles of genetic engineering and biotechnology by integrating computational and engineering approaches to the design and construction of novel biological systems.

This volume addresses some of the major technical challenges stand in the way of achieving a radical step-change in our ability to engineer complex multi-scaled biological systems. These include: the application of computation intelligence to the design of synthetic microbial systems, design automation and constraints; the impact of noise and stochasticity; the engineering of biosensors; the characteristic of a model bacterial chassis. A key issue in Synthetic Biology is that of its social dimensions and a chapter is dedicated to the important issue.

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Microbiologists, lab researchers, students



Book information

  • Published: November 2013
  • ISBN: 978-0-12-417029-2

Table of Contents

  1. Computational Intelligence in the Design of Synthetic Microbial Genetic Systems
    Jennifer S. Hallinan
  2. Constraints in the Design of the Synthetic Bacterial Chassis
    Antoine Danchin and Agnieszka Sekowska
  3. Social Dimensions of Microbial Synthetic Biology
    Jane Calvert and Emma Frow
  4. Bacillus Subtilis: Model Gram-positive Synthetic Biology Chassis
    Colin R. Harwood, Suzanne Pohl, Wendy Smith and Anil Wipat
  5. Engineering Microbial Biosensors
    Lisa Goers, Nicolas Kylilis, Marios Tomazou, Ke Yan Wen, Paul Freemont and Karen Polizzi
  6. Noise and Stochasticity in Gene Expression - A Pathogenic Fate determinant
    Mikkel Girke Jørgensen, Renske van Raaphorst and Jan-Willem Veening
  7. Platforms for Genetic Design Automation
    Chris J. Myers