Microbial Glycobiology book cover

Microbial Glycobiology

Structures, Relevance and Applications

This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications.

Audience
Researchers and graduate students in both academia and industry:

Microbiologists
Infectious disease specialists

These researchers are trying to understand how certain microbial pathogens (protozoa, bacteria, fungi, viruses etc) cause disease in humans. With insights from microbial glycobiology new diagnostic methods can be designed to detect the infectious agent and also to determine if one bug is more virulent than another, thus, helping disease diagnosis.

Microbial glycobiology allows them to examine the role that sugars play in the disease process and help them determine a way to prevent a pathogen causing disease. Hence, new insights will be gained that could aid boost the immune system, thereby new biotheraputics and vaccines are being developed

Biochemists
Carbohydrate chemists (analytical and synthetic)

By determining the structure of glycosylated proteins, lipids and other natural products from microbes, researchers can reveal the location of the sugars. They then have the ability to modify and control which sugars are attached and exactly how they are attached. This is important as it enables them to modify glycosylated biomolecules that are important in disease processes and turn these into better drugs.

Researchers in biomedical, diagnostic and biopharmaceutical companies
Pharmacologists are using microbial glycobiology to produce carbohydrate-based diagnostics, vaccines, drugs and immunotherapeutics.

From the insights gained of the enzymes used in the natural synthesis of the glycosylated molecules in microbes, manipulations using these enzymes can be made to synthesise newer glycosylated structures that can be used in therapeutics or for obtaining correct glycosylation of cloned human proteins used in biotherapeutics.

Since glycosylation determines the half-life of many biotherapeutics, usage of knowledge from glycosylation systems from microbes can help manufacture more effective therapeu

Hardbound,

Published: August 2009

Imprint: Academic Press

ISBN: 978-0-12-374546-0

Contents

  • Part I. Microbial glycolipids, glyoproteins and glycopolymers  1. Overview of the glycosylated components of the bacterial cell wall   2. Bacterial cell wall envelope peptidoglycan   3. Core oligosaccharide and lipid A components of lipopolysaccharides   4. O-Specific polysaccharides of Gram-negative bacteria   5. Teichoic acids, lipoteichoic acids, and related cell wall glycopolymers of Gram-positive bacteria   6. Bacterial capsular polysaccharides and exopolysaccharides   7. Bacterial surface layer glycoproteins and “non-classical” secondary cell wall polymers   8. Glycosylation of bacterial and archaeal flagellins   9. Glycosylated components of the mycobacterial cell wall: structure and function   10. Glycoconjugate structure and function in fungal cell walls   11. Cytoplasmic carbohydrate molecules: trehalose and glycogen   12. Glycosylated compounds of parasitic protozoa   13. Analytical approaches towards the structural characterization of microbial wall glycopolymers   14. Single-molecule characterization of microbial polysaccharides   15. Viral surface glycoproteins in carbohydrate recognition: structure and modeling Part II. Synthesis of microbial glycosylated components; A. Biosynthesis and biosynthetic processes  16. Biosynthesis of bacterial peptidoglycan   17. Biosynthesis and membrane assembly of lipid A   18. Biosynthesis of O-antigen chains and assembly   19. Biosynthesis of cell wall teichoic acid polymers   20. Biosynthesis and assembly of capsular polysaccharides   21. Biosynthesis of the mycobacterial cell envelope components   22. Biosynthesis of fungal and yeast glycans B. Chemical synthesis   23. Chemical synthesis of bacterial lipid A   24. Chemical synthesis of the core oligosaccharide of bacterial lipopolysaccharide   25. Chemical synthesis of lipoichoic acid and derivatives   26. Chemical synthesis of parasitic glycoconjugates and phosphoglycans  Part III. Microbe-host glycosylated interactions   27. Bacterial lectin-like interactions in cell recognition and adhesion   28. Lectin-like interactions in virus-cell recognition: human immunodeficiency virus and C-type lectin interactions   29. Sialic acid-specific microbial lectins    30. Bacterial toxins and their carbohydrate receptors at the host-pathogen interface   31. Toll-like receptor recognition of lipoglycans, glycolipids and lipopeptides   32. NOD receptor recognition of peptidoglycan   33. Microbial interaction with mucus and mucins   34. Mannose-fucose recognition by DC-SIGN   35. Host surfactant proteins in microbial recognition   36. T-cell recognition of microbial lipoglycans and glycolipids  Part IV. Biological relevance of microbial glycosylated components; A. Environmental relevance   37. Extracellular polymeric substances in microbial biofilms   38. Physico-chemical properties of microbial glycopolymers   39. Microbial biofilm-related polysaccharides in biofouling and corrosion   40. Microbial glycosylated components in plant disease  B. Medical relevance   41. Antigenic variation of microbial surface glycosylated molecules   42. Phase variation of bacterial surface glycosylated molecules in immune evasion   43. Molecular mimicry of host glycosylated structures by bacteria   44. Role of microbial glycosylation in host cell invasion  Part V. Biotechnological and medical applications   45. Exopolysaccharides produced by lactic acid bacteria in food and probiotic applications   46. Industrial exploitation by genetic engineering of bacterial glycosylation systems   47. Glycomimetics as inhibitors in anti-infection therapy   48. Bacterial polysaccharide vaccines: glycogonjugates and peptide-mimetics   49. Immunomodulation by zwitterionic polysaccharides   50. Future potential of glycomics in microbiology and infectious diseases 

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