MicroRNA in Regenerative Medicine book cover

MicroRNA in Regenerative Medicine

This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering.

Regulating virtually all biological processes, the genome’s 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering


Graduate students studying stem cell biology and regenerative and reparative medicine

Hardbound, 1288 Pages

Published: December 2014

Imprint: Academic Press

ISBN: 978-0-12-405544-5


  • Part 1: Stem Cells
    1. miR Biogenesis in Regenerative Medicine
      Subhadip Ghatak
    2. Control of Pluripotency and Reprogramming
      Jose Javier Otero, Patrick Gygli and Catherine Czeisler
    3. Epigenetic Modification of MicroRNA
      Subhadip Ghatak
    4. miRNA in bone marrow-derived mesenchymal stem cells
      Kenneth W. Liechty and Junwang Xu
    5. miRNA in Cancer Stem Cells
      Fazlul Sarkar and Yiwei Li
    6. Neural Stem Cells
      Harold Cremer
    7. Embryonic Stem Cells
      Ales Hampl
    8. Myelopoiesis
      Stefan J. Erkeland
    9. Stem Cell Renewal
      Prabha Sampath
    10. miRNA in Endothelial Progenitor Cells
      Alex F. Chen and Jiemei Wang

    Part 2: Development
    11. MicroRNA Function in Muscle Homeostasis  and Regenerative Medicine
      Denis Guttridge
    12. MicroRNAs in Skin Fibrosis
      Jared Jagdeo
    13. Hematopoietic Cell Development
      Ryan M. O'Connell and Dominique Kagele
    14. Bone Formation and Homeostasis
      Tatsuya Kobayashi, Garyfallia Papaioannou and Thomas Lisse
    15. Lung Development
      Lin Liu
    16. Pancreatic Buds and Islets
      Ricardo Pastori
    17. Skeletal Muscle Differentiation
      Huating Wang
    18. Brain Development
      Marion Coolen and Dr. Bally-Cuif
    19. Retinal Development
      Nicola Antonio Maiorano
    20. Neural Crest Development
      Chandra Shekhar Mayanil
    21. Adipogenesis and Obesity
      Leluo Guan and Josue Romao

    Part 3: Repair
    22. Cardiac Remodeling and Repair
      Chandan K. Sen and K Haider
    23. Vascular Remodeling and Repair
      Costanza Emanueli and Lynsey Howard
    24. Skin Wound Healing
      Jaideep Banerjee
    25. Bone Repair
      Anne Delany
    26. Spinal Injury
      Esmerina Tili
    27. Angiogenesis
      Yuk Cheung Chan
    28. Inflammation
      Sashwati Roy
    29. mTOR Function
      John Houle
    30. Hypoxia Response
      Chandan K. Sen and Mithun Sinha
    31. microRNAs and exosomes: promises in cancer diagnosis and therapy
      Hidetoshi Tahara
    32. Organ Transplantation
      Christopher Taylor Barry

    Part 4: Regeneration
    33. Neurogenesis
      Laurent Nguyen
    34. Transitions: EMT, reverse EMT and EndoMT
      Mitsuo Sato
    35. Cardiac Regeneration
      Maurizio C. Capogrossi
    36. MicroRNAs in Liver Regeneration
      Amar Deep Sharma

    Part 5: Methodology
    37. miRNA Technology and Small Molecule Delivery
      Detlev Boison

    Part 6: Intervention
    38. Drug-miRNA Cross-talk
      George A. Calin and Paloma del Carmen Monroig
    39. microRNA Delivery
      Roberto Gambari
    40. RNA-based Therapies for Bone Diseases
      Maria Luisa Brandi
    41. Micro RNA-mediated Regulation of Cardiovascular Differentiation and Therapeutic Implications
      Thomas Thum
    42. Circulating miRNAs as Biomarkers
      Melissa G. Piper and Clay B. Marsh

    Part 7: Tissue Engineering
    43. Nuclear architecture and transcriptional regulation of microRNAs
      Sreenivas Chavali
    44. miRNA in Tissue Engineering
      Martin C. Harmsen


advert image