MicroRNA in Regenerative Medicine

Edited by

  • Chandan Sen, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA

This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering.

Regulating virtually all biological processes, the genome’s 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering

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Graduate students studying stem cell biology and regenerative and reparative medicine


Book information

  • Published: December 2014
  • ISBN: 978-0-12-405544-5


"...comprehensive in its discussion of regenerative medicine and the current knowledge about microRNA in tissue regeneration.  Score: 68 - 2 Stars"-- Doody's, MicroRNA in Regenerative Medicine

Table of Contents

Part 1: Stem Cells
1. miR Biogenesis in Regenerative Medicine
  Subhadip Ghatak
2. Control of Pluripotency and Reprogramming
  Jose Javier Otero, Patrick Gygli and Catherine Czeisler
3. Epigenetic Modification of MicroRNA
  Subhadip Ghatak
4. miRNA in bone marrow-derived mesenchymal stem cells
  Kenneth W. Liechty and Junwang Xu
5. miRNA in Cancer Stem Cells
  Fazlul Sarkar and Yiwei Li
6. Neural Stem Cells
  Harold Cremer
7. Embryonic Stem Cells
  Ales Hampl
8. Myelopoiesis
  Stefan J. Erkeland
9. Stem Cell Renewal
  Prabha Sampath
10. miRNA in Endothelial Progenitor Cells
  Alex F. Chen and Jiemei Wang

Part 2: Development
11. MicroRNA Function in Muscle Homeostasis  and Regenerative Medicine
  Denis Guttridge
12. MicroRNAs in Skin Fibrosis
  Jared Jagdeo
13. Hematopoietic Cell Development
  Ryan M. O'Connell and Dominique Kagele
14. Bone Formation and Homeostasis
  Tatsuya Kobayashi, Garyfallia Papaioannou and Thomas Lisse
15. Lung Development
  Lin Liu
16. Pancreatic Buds and Islets
  Ricardo Pastori
17. Skeletal Muscle Differentiation
  Huating Wang
18. Brain Development
  Marion Coolen and Dr. Bally-Cuif
19. Retinal Development
  Nicola Antonio Maiorano
20. Neural Crest Development
  Chandra Shekhar Mayanil
21. Adipogenesis and Obesity
  Leluo Guan and Josue Romao

Part 3: Repair
22. Cardiac Remodeling and Repair
  Chandan K. Sen and K Haider
23. Vascular Remodeling and Repair
  Costanza Emanueli and Lynsey Howard
24. Skin Wound Healing
  Jaideep Banerjee
25. Bone Repair
  Anne Delany
26. Spinal Injury
  Esmerina Tili
27. Angiogenesis
  Yuk Cheung Chan
28. Inflammation
  Sashwati Roy
29. mTOR Function
  John Houle
30. Hypoxia Response
  Chandan K. Sen and Mithun Sinha
31. microRNAs and exosomes: promises in cancer diagnosis and therapy
  Hidetoshi Tahara
32. Organ Transplantation
  Christopher Taylor Barry

Part 4: Regeneration
33. Neurogenesis
  Laurent Nguyen
34. Transitions: EMT, reverse EMT and EndoMT
  Mitsuo Sato
35. Cardiac Regeneration
  Maurizio C. Capogrossi
36. MicroRNAs in Liver Regeneration
  Amar Deep Sharma

Part 5: Methodology
37. miRNA Technology and Small Molecule Delivery
  Detlev Boison

Part 6: Intervention
38. Drug-miRNA Cross-talk
  George A. Calin and Paloma del Carmen Monroig
39. microRNA Delivery
  Roberto Gambari
40. RNA-based Therapies for Bone Diseases
  Maria Luisa Brandi
41. Micro RNA-mediated Regulation of Cardiovascular Differentiation and Therapeutic Implications
  Thomas Thum
42. Circulating miRNAs as Biomarkers
  Melissa G. Piper and Clay B. Marsh

Part 7: Tissue Engineering
43. Nuclear architecture and transcriptional regulation of microRNAs
  Sreenivas Chavali
44. miRNA in Tissue Engineering
  Martin C. Harmsen