Metal Transporters book cover

Metal Transporters

This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others.

Audience

Researchers in biochemistry, molecular and cellular biology.

Hardbound, 456 Pages

Published: October 2012

Imprint: Academic Press

ISBN: 978-0-12-394390-3

Contents

    1. Regulation of Copper Transporters in Human Cells
    2. Nesrin M. Hasan and Svetlana Lutsenko

    3. Transferrin Mediated Cellular Iron Delivery
    4. Ashley N. Steere and Anne B. Mason

    5. Structure, Function and Binding Selectivity and Stereoselectivity of Siderophore-Iron Outer Membrane Transporters
    6. Isabelle J. Schalk, Gaëtan L. A. Mislin and Karl Brillet

    7. Iron Transport Machinery of Human Cells: Players and their Interactions
    8. Ningning Zhao and Caroline A. Enns

    9. Structure and Function of Copper Uptake Transporters
    10. Christopher R Pope, Adrian G Flores, Jack H Kaplan and Vinzenz M Unger

    11. Toward a Molecular Understanding of Metal Transport by P1B-Type ATPases
    12. Amy C. Rosenzweig and José M. Argüello

    13. Metal Export by CusCFBA, the Periplasmic Cu(I)/Ag(I) Transport System of E. coli
    14. Tiffany D. Mealman, Ninian J. Blackburn and Megan M. McEvoy

    15. Molecular Architecture and Function of ZnT Transporters
    16. Taiho Kambe

    17. The Cation Selectivity of the ZIP Transporters
    18. Robert E. Dempski

    19. Nramp: from Sequence to Structure and Mechanism of Divalent Metal Import
    20. Mathieu FM. Cellier

    21. Genetic and Biochemical Approaches for Studying the Yellow Stripe-Like (YSL) Transporter Family in Plants
    22. Sarah S. Conte and Elsbeth L. Walker

    23. Pathways of Arsenic Uptake and Efflux
    24. Hung-Chi Yang, Hsueh-Liang Fu , Yung-Feng Lin and Barry P. Rosen

    25. Extra Heme Uptake and the Challenges of Bacterial Cell Membranes
    26. Aaron D. Smith and Angela Wilks

    27. The Mechanisms of Mg2+ and Co2+ Transport by the CorA Family of Divalent Cation Transporters

    Albert Guskov and Said Eshaghi

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