Metabolic Syndrome in the 21st Century book cover

Metabolic Syndrome in the 21st Century

El sindrome metabolico es uno de los retos mas intrigantes y fascinantes de la medicina contemporanea. Se trata de una patologia en la que confluyen problemas de distintas areas de la medicina: diferentes grados de hipertension, acumulacion de grasa, insulinoresistencia, estados protrombotico y proinflamatorio, todos juntos en la misma persona. Esta concurrencia de factores hace que la persona tenga un riesgo mucho mayor de sufrir enfermedad cardiovascular o diabetes mellitus tipo 2, que lo que la suma de los factores individuales supondria.

Hardbound,

Published: November 2005

Imprint: Elsevier Espana

ISBN: 978-84-8174-892-5

Contents

  • Origin and Development of the Metabolic Syndrome. Intracellular Signaling Mechanisms Involved in Insulin Action. Cellular Models for the Study of Type 2 Diabetes. Transgenic Animal Models and the Metabolic Syndrome. On the Relationship Between Aging and Metabolic Syndrome with Special Reference to Insulin Resistance and Hyperinsulinemia. Gene/environment Interaction: Thrifty Genotype Versus Thrifty Phenotype. Epidemiology of the Metabolic Syndrome. Genetic Susceptibility to the Metabolic Syndrome. Genomic of Skeletal Muscle and Its Implications in the Metabolic Syndrome. The Metabolic Syndrome: Obesity and Diet Modulates the Expression of its genetic Predisposition. Pathophysiology of Insulinaction in Humans. Leptin, Insulin, and Blood-Brain Barrier Relations in Obesity. Chronic Inflammatory Hypothesis in the Metabolic Syndrome. Metabolic Syndrome and Adipokine. Role of PPARs in the pathogenesis of Metabolic Syndrome. The Lipotoxicity and Glucotoxicity Hypothesis in the Metabolic Syndrome and Type 2 Diabetes. Thermogenesis and the Metabolic Syndrome. Nitric Oxide and Cell Metabolism Dysfunction in Metabolic Syndrome. Endothelial Dysfunction in the Metabolic Syndrome. Hypertension in the Metabolic Syndrome. Dyslipidemia in Metabolic Syndrome. Alterations in Thrombosis and Fibrinolysis in Metabolic Syndrome. Insulin Resistance and Coronary Heart Disease. Nonalcoholic Fatty Liver Disease: a new entry in the Metabolic Syndrome? Hyperinsulinism, Insulin Resistance and Fertility. Nutritional Treatment in the Metabolic Syndrome. Drug Treatment in the Metabolic Syndrome. The Metabolic Syndrome: Lifestyle, Drugs, or Both?

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