Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells
- T.E. Gram, National Cancer Institute, Division of Cancer Treatment, Bethesda, MD, USA
Research has shown that the lung is capable of metabolically activating xenobiotics into intermediates that can covalently bind to pulmonary tissue. Further, it has been shown that the lung consists of many distinct cell types with the ability to take up and sequester metabolically unchanged drugs and chemicals that are ultimately toxic in effect. This volume reflects the extent of these developments and provides a state-of-the art reference in a rapidly evolving field incorporating both drug metabolism and pulmonary toxicology research.
For researchers in pharmacology, toxicology, environmental sciences and pulmonary medicine.