Biology and Pathobiology

Edited By

  • Rogerio Lobo, Columbia University, New York, U.S.A.
  • Jennifer Kelsey, Stanford University, California, U.S.A.
  • Robert Marcus, Stanford University, Palo Alto, California, U.S.A.


Researchers, professionals, and academic clinicians in endocrinology, public health, obstetrics and gynecology, epidemiology, and related desciplines.


Book information

  • Published: April 2000
  • ISBN: 978-0-12-453790-3


"This text is broad in its presentation. Readers who care for menopause-age women will find ample material on physiology, symptom treatment, and health promotion, with accompanying information on the supportive literature." -Mary Ellen Rousseau, Yale College of Nursing for JOURNAL OF PSYCHOSOMATIC RESEARCH (December 2001) "Almost every conceivable aspect of menopause is covered. ...a worthy reference for experts in menopause from all disciplines. ...the aggregation of so much relevant information in one book is an important asset." -Sarah L. Berga, University of Pittsburgh School of Medicine for NEW ENGLAND JOURNAL OF MEDICINE (December 2000)

Table of Contents

Basic Biology:The Molecular Pharmacology of the Estrogen and Progesterone Receptors.Ovarian Anatomy and Physiology.Regulation of the Hypothalamic-Pituitary-Gonadal Axis: Role of Gonadal Steroids and Implications for the Menopause.Gonadotropins and Menopause: New Markers.Genetic Programming in Ovarian Development and Oogenesis.Neuroendocrine Regulation of the Perimenopause Transition.Changes in Men as They Age: The "Manopause."Premature Ovarian Failure.Perimenopausal Changes in FSH, the Inhibins and the Circulating Steroid Hormone Milieu.Epidemiology:Methodologic Challenges in the Study of Menopause.SWAN: A Multi-center, Multi-ethnic, Commnity-based Cohort Study of Women and the Menopausal Transition.Demographics, Environmental Influences, Ethnic And International Differences In The Menopausal Experience.Distinguishing the Effects of Age From Those of Menopause.Menopausal Systems Pathophysiology:Menopausal Hot Flashes.Menopause and Cardiovascular Disease.Insulin Resistance, Body Weight, Obesity, Body Composition and the Menopausal Tradition.Influence of Estrogen on Collagen.The Growth Hormone IGF-I Axis and Menopause.Bone & Calcium.Menopause and the Skin.Estrogen Therapy and the Brain.Gyno-Urinary System.Is There a Relationship Between Menopause and Mood?Immunologic Aspects of Menopause.Cancers.Sexuality.Intervention:Historical Perspectives.Prevention Trials in Perimenopausal Women and Postmenopausal Women.Estrogens: Different Types, Properties.Progestogens.Androgens.The Alternative Therapies to Hormone Replacement Therapies.Calcium Nutriture: A Model System for Understanding Menopause-Nutrient Interactions.Exercise.Estrogens and Osteoporosis.Osteoarthritis and Menopause.The Epidemiology of Cardiovascular Disease and Postemenopausal Hormone Therapy.Interventions for the Control of Symptoms. Effects of Steroids on Mood/Depression.Hormone Replacement Therapy and Breast Cancer.HRT and Risk of Endometrial Cancer.Risk of Pulmonary Embolism/Venous Thrombosis.Combined Estrogen-Androgen Replacement Therapy: Benefits and Risks.Biology of DHEA.Menopausal Issues for Older Women.Decision Analysis Applied to Postmenopausal Hormone Replacement Therapy.