Membrane Proteins as Drug Targets

Edited by

  • Charles.A Lunn, Schering-Plough Research Institute, New Jersey, USA

Membrane proteins continue to be prime drug targets because they perform essential processes in the cell including controlling the flow of information and materials between cells and mediating activities like hormone action and nerve impulses. The study of membrane proteins could lead to new and improved pharmaceutical treatments for a wide range of illnesses such as heart disease, cystic fibrosis and depression.

This volume reviews the latest developments in the field.

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Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.


Book information

  • Published: August 2010
  • ISBN: 978-0-12-381288-9


"Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal

Table of Contents

  1. Inverse Agonism at Serotonin and Cannabinoid Receptors

         Vincent J. Aloyo, Kelly A. Berg, William P. Clarke, Umberto Spampinato, and John A. Harvey

    2.    G protein-coupled receptor heteromers as new targets for drug development

      Sergi Ferré, Gemma Navarro, Vicent Casadó, Antoni Cortés, Josefa Mallol, Enric I. Canela, Carme Lluís and Rafael Franco

    3.    Receptor activity modifying proteins and their potential as drug targets

      Denise L. Wootten, John Simms, Debbie L. Hay, Arthur Christopoulos and Patrick M. Sexto

      4.  Regulators of G Protein Signaling Proteins As Targets For Drug Discovery

      Benita Sjögren, Levi L. Blazer and Richard R. Neubig

    5.    Escorts Take the Lead: Molecular Chaperones as Therapeutic Targets

      Dumaine Williams and Lakshmi A. Dev

      6.    The T1r2/T1r3 Sweet Receptor and Trpm5 Ion Channel: Taste Targets With Therapeutic Potential

      Dennis Sprous and R. Kyle Palmer

      7.     Membrane-associated enzymatic synthesis

      Edward A. Esposito and Robert Weis