Medicinal Chemistry

The Role of Organic Chemistry in Drug Research


  • C. Ganellin, University College London, UK
  • Stanley Roberts

This Second Edition covers exciting progress recently made with individual drugs and includes a special chapter on the impact of molecular biology on drug design. Other additions to the Second Edition include structure-activity relationships, the role of molecular biology in drug discovery, and drug access and prodrugs. Written for students considering a research career in drug development, this volume is conveniently divided into two parts. The first half introduces readers to the mechanisms of action of drugs and the approaches adopted in designing new drugs. The second half contains chapters written by the discoverers or developers of individual successful drugs who trace the history of the drugs to the present day.
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This book is aimed primarily at final year organic/medicinal chemists considering a research career in drug development.Recent exiting progress is reported in the chapters on individual drugs by their developers for the second edition of Medicinal Chemistry. In addition, this volume benefits from new chapters dealing with structure-activity relationships, the role of molecular biology in drug discovery, and drug acccess and prodrugs.


Book information

  • Published: December 1992
  • ISBN: 978-0-12-274120-3


"This book provides thorough and readable accounts of drug discovery by persons directly involved and shoud fine use among students of medicinal chemistry and organic chemists wanting to learn more about how drugs are developed."
--Journal of the American Chemical Society

Table of Contents

Contributors Preface1. Introduction to Receptors and the Action of Drugs2. Structure and Atalytic Properties of Enzymes3. Receptor Pharmacology4. Drug Access and Prodrugs5. QSAR and the Role of Computers in Drug Design6. The Current Status and Future Impact of Molecular Biology in Drug Discovery7. General Approaches to Discovering New Drugs: An Historical Perspective. 8. Discovery and Development of Cromakalim and Related Potassium Channel Activators 9. Angiotension-Converting Enzyme (ACE) inhibitors and the Design of Cilazapril10. Beta Blockers11. Salbutamol: A Selective B2-Stimulant Bronchodilator12. Discovery of CCimetidine, Ranitidine and Other H2-Receptor Histamine Antagonists13. Fluconazole, An Orally Active Antifungal Agent14. Clavulanic Acid and Related Compounds: Inhibitors of B-Lactamase EnzymesIndex