Medicinal Chemistry of Anticancer DrugsBy
- Carmen Avendano
- J. Carlos Menendez
Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures.
Researchers involved in oncology and pharmaceutical, medicinal and organic chemistry; Practitioners; Advanced undergraduate and graduate students in medicinal chemistry and pharmacology.
Hardbound, 400 Pages
Published: April 2008
- Introduction to anticancer chemotherapy; Antimetabolites; Anticancer drugs that inhibit hormone action; Anticancer drugs acting via radical species. Photosensitizers and photodynamic therapy of cancer; DNA alkylating agents; Alkylating and non-alkylating compounds interacting with the DNA minor groove; DNA intercalation and inhibition of topoisomerases; Anticancer drugs targeting tubulin and microtubules; Drugs targeting signaling pathways for tumour cell growth and proliferation; Other approaches to targeted therapy; Drug targeting in anticancer chemotherapy; Resistance to antitumour agents and drugs that modulate it; Cancer chemoprevention.