Medicinal Chemistry of Anticancer Drugs


  • Carmen Avendano, Department of Organic Chemistry, Farmaceutica, Facultad de Farmacia, Madrid, Spain
  • J. Carlos Menendez, Department of Organic Chemistry, Farmaceutica, Facultad de Farmacia, Madrid, Spain

Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures.
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Researchers involved in oncology and pharmaceutical, medicinal and organic chemistry; Practitioners; Advanced undergraduate and graduate students in medicinal chemistry and pharmacology.


Book information

  • Published: April 2008
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-52824-7

Table of Contents

1. Introduction to anticancer chemotherapy
2. Antimetabolites
3. Anticancer drugs that inhibit hormone action
4. Anticancer drugs acting via radical species. Photosensitizers and photodynamic therapy of cancer.
5. DNA alkylating agents
6. Alkylating and non-alkylating compounds interacting with the DNA minor groove.
7. DNA intercalation and inhibition of topoisomerases
8. Anticancer drugs targeting tubulin and microtubules
9. Drugs targeting signaling pathways for tumour cell growth and proliferation
10.Other approaches to targeted therapy
11.Drug targeting in anticancer chemotherapy
12.Resistance to antitumour agents and drugs that modulate it
13.Cancer chemoprevention