Mechanisms of Memory


  • J. David Sweatt, McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

This book stands as the first unified overview of the cellular and molecular mechanisms underlying higher-order learning and memory. It integrates modern discoveries concerning learning and memory disorders such as mental retardation syndromes and Alzheimer's Disease, while also emphasizing the results gained from the cutting-edge research methodologies of genetic engineering, complex behavioral characterization, proteomics, and molecular biology. This book provides a foundation of experimental design that will be useful to all students pursuing an interest in laboratory research. This book is an enlightening and invaluable resource for anyone concerned with memory mechanisms.
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Neuroscience graduate students and researchers interested in learning and memory, as well as neurologists and psychiatrists.


Book information

  • Published: October 2003
  • ISBN: 978-0-12-678957-7


"The book is well written and includes interesting and illustrative text inserts as well as colorful fugures with detailed explanations. Mechanisms of Memory is a successful integration of recent discoveries and technological advances applied to learning and memory at many different levels that will appeal to its target audience of advanced undergraduates and graduates across a number of disciplines." --AMERICAN JOURNAL OF PSYCHIATRY (November 2005, 162:11) "This is an exceptional book in more than one aspect. David Sweatt has written a monograph in which long term potentiation (LTP) is central issue. However, this book is not an endless presentation of all the numerous experiments into a context of learning and memory...the book presents a real opportunity for the advanced student, and the interested scientists, to learn more about LTP and how to put it into a perspective...The illustrations in the book are of high quality, informative and to the point. Every chapter is introduced at an abstract level, the last item I wanted to mention which makes this a special book, bringing long term reminiscences of Rothko and Pollock." - Journal of Chemical Neuroanatomy (2005)

Table of Contents

Introduction - the basics of psychological learning and memory theoryRodent behavioral learning and memory modelsThe hippocampus serves a role in multimodal information processing, and memory consolidationLong-term Potentiation as a physiological phenomenonComplexities of Long-term PotentiationThe biochemistry of LTP inductionBiochemical mechanisms for short-term information storage at the cellular levelBiochemical mechanisms for long-term information storage at the cellular levelLTP does not equal memoryInherited disorders of human memory-mental retardation syndromesAging-related memory disorders-Alzheimer's DiseaseThe chemistry of perpetual memory