Mechanisms and Pathways of Heterotrimeric G Protein Signaling book cover

Mechanisms and Pathways of Heterotrimeric G Protein Signaling

This volume in the Advances in Protein Chemistry series features cutting-edge articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric GƒÑƒnƒnproteins; How do receptors activate G proteins; Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads; Activation of G protein coupled receptors; Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells; Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteins.

Audience
Researchers in biochemistry, molecular biology, cell biology, and biophysics.

Hardbound, 290 Pages

Published: October 2007

Imprint: Academic Press

ISBN: 978-0-12-034288-4

Contents

  • 1. Structural basis of effector regulation and signal termination in heterotrimeric GƒÑƒnƒnproteinsStephen R. Sprang, Zhe Chen and Xinlin Du2. How do receptors activate G proteins?William M. Oldham and Heidi E. Hamm3. Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beadsTione Buranda, Anna Waller, Yang Wu, Peter C. Simons, Sean Biggs, Eric R. Prossnitz and Larry A. Sklar4. Activation of G protein coupled receptorsXavier Deupi and Brian Kobilka5. Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cellsMartin J. Lohse, Carsten Hoffmann, Viacheslav O. Nikolaev, Jean-Pierre Vilardaga and Moritz Bunemann6. Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteinsPaul C. Sternweis, Angela M. Carter, Zhe Chen, Shahab M. Danesh, Ying-Fan Hsiung, and William D. Singe

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