McAlpine

McAlpine's Multiple Sclerosis

Since 1955, this landmark masterwork has been revered for its authoritative presentation of the entire state of scientific and clinical knowledge about multiple sclerosis. The state-of-the-art 4th Edition presents the most recent information on the genetics and epidemiology, clinical neurology, pathogenesis, and management of this common neurological disease. Amply illustrated and referenced and beautifully written, McAlpine's Multiple Sclerosis has been described as "A standard reference for multiple sclerosis researchers, embryonic 'MS-ologists' and hard-pressed clinical neurologists alike" (Brain, review of the last edition).

Audience
Neurologists, Libraries, MS patients, Pharmaceutical workers

Hardbound, 992 Pages

Published: December 2005

Imprint: Churchill Livingstone

ISBN: 978-0-443-07271-0

Contents

  • SECTION ONE: THE STORY OF MULTIPLE SCLEROSIS


    1. The story of multiple sclerosis

    The evolving concept of multiple sclerosis

    Naming and classifying the disease: 1868-1983

    Clinical descriptions of multiple sclerosis: 1838-1981

    Personal accounts of multiple sclerosis: 1824-1991

    The social history of multiple sclerosis: 1945-1998

    The pathogenesis and clinical anatomy of multiple sclerosis: 1849-1977

    The laboratory science of multiple sclerosis: 1912-1981

    Discovery of glia and remyelination: 1858-1988

    The aetiology of multiple sclerosis: 1883-1976

    Attitudes to the treatment of multiple sclerosis: 1841-1983


    SECTION TWO: THE CAUSE AND COURSE OF MULTIPLE SCLEROSIS


    2. The distribution of multiple sclerosis

    The rationale for epidemiological studies in multiple sclerosis

    Definitions and statistics in epidemiology

    Strategies for epidemiological studies in multiple sclerosis

    The geography of multiple sclerosis

    Epidemics and clusters of multiple sclerosis

    The environmental factor in multiple sclerosis


    3. The genetics of multiple sclerosis:

    Genetic analysis of multiple sclerosis

    Methods of genetic analysis

    Racial susceptibility

    Sex differences in susceptibility

    Familial multiple sclerosis

    Candidate genes in multiple sclerosis

    Systematic genome screening

    Lessons from genetic studies of experimental allergic encephalomyelitis

    Conclusions


    4. The natural history of multiple sclerosis

    Introduction

    Definitions

    Onset

    Course

    Inter-individual variability

    Factors affecting the prognosis

    General considerations

    Environmental influences


    Chapter 5: The aetiology of multiple sclerosis: an epitome


    SECTION THREE: THE CLINICAL FEATURES AND DIAGNOSIS OF MULTIPLE SCLEROSIS


    6. The symptoms and signs of multiple sclerosis.

    Multiple sclerosis as a neurological illness

    Initial symptoms

    Symptoms and signs in the course of the disease

    Individual symptoms and sign

    Associated diseases

    Conclusion


    7. The diagnosis of multiple sclerosis

    Diagnostic criteria for multiple sclerosis

    Selection of investigations

    Magnetic resonance imaging

    Evoked potentials

    Examination of the cerebrospinal fluid

    A strategy for the investigation of demyelinating disease


    8. The differential diagnosis of multiple sclerosis

    The spectrum of disorders mimicking multiple sclerosis

    Diseases that may cause multiple lesions of the CNS and also often follow a relapsing remitting course

    Systematized central nervous system diseases

    Isolated or monosymptomatic CNS syndromes

    Non organic symptoms

    How accurate is the diagnosis of multiple sclerosis?


    9. Multiple sclerosis in the individual and in groups: a conspectus

    The typical case

    Isolated syndromes and their outcome: judicious use of investigations and critique of the new diagnostic criteria

    Co-morbidity and associated diseases

    Situations in which alternative diagnoses should be considered

    When to ignore “inconvenient” laboratory results or clinical findings: taking the best position

    “Pathognomonic” and “un-heard of” features of multiple sclerosis


    SECTION FOUR: THE PATHOGENESIS OF MULTIPLE SCLEROSIS


    10. The neurobiology of multiple sclerosis.

    Organisation in the central nervous system

    Development of the central nervous system

    Macroglial lineages in the rodent and human nervous system

    Axon-glial interactions and myelination

    Demyelination

    Axon degeneration and restoration of function
    Remyelination


    11. The immunology of inflammatory demyelinating disease

    Multiple sclerosis as an autoimmune disease

    Immune responses: innate and adaptive

    T lymphocytes

    B lymphocytes

    Autoimmunity and self tolerance in the central nervous system

    Regulation of central nervous system autoimmune responses

    Immune reactivity in the central nervous system

    Pathogenesis of demyelination and tissue damage

    Peripheral blood biomarkers for multiple sclerosis and disease activity

    Markers of multiple sclerosis and disease activity in cerebrospinal fluid

    Conclusion


    12. The pathology of multiple sclerosis

    Introduction

    Pathological classification of demyelinating diseases

    The demyelinated plaque

    Immunopathology of inflammation

    Demyelination and oligodendroglial damge

    Remyelination

    Axonal pathology

    Grey matter pathology / cortical plaques

    Astroglia reaction

    Abnormalities in the “normal” white matter

    Distribution of lesions in the nervous system

    Is there evidence for an infectious agent in the lesions of multiple sclerosis?

    Dynamic evolution of multiple sclerosis pathology

    Differences between acute relapsing and progressive multiple sclerosis

    Molecular approaches to the study of the MS lesion: Global profiling of transcriptome and proteome.

    Association of multiple sclerosis with other diseases

    Conclusions


    13. The pathophysiology of multiple sclerosis

    Introduction

    Methods for exploring the pathophysiology of multiple sclerosis

    Relapsing remitting multiple sclerosis: loss of function due to conduction block

    Relapsing remitting multiple sclerosis: recovery of function and remission

    Physiological explanations for other clinical symptoms in multiple sclerosis

    Permanent loss of function in the context of disease progression

    Summary


    SECTION FIVE: THE TREATMENT OF MULTIPLE SCLEROSIS


    15. Care of the person with multiple sclerosis

    General approach to the care of people with multiple sclerosis

    The early stages of disease: minimal disability

    The middle stages of disease: moderate disability

    The later stages of disease: severe disability

    Guidelines for the management and investigation of multiple sclerosis

    Conclusion


    16. Treatment of the acute relapse

    The features of active multiple sclerosis

    The treatment of relapse in multiple sclerosis

    Other approaches to the treatment of acute relapse

    Treatment of acute optic neuritis

    Management of other central nervous system demyelinating disorders

    Adverse effects of corticosteroids

    Mode of action of corticosteroids

    Practice Guidelines


    17. The treatment of symptoms in multiple sclerosis and the role of rehabilitation

    The general principles of symptomatic treatment in multiple sclerosis

    Disturbances of autonomic function

    Mobility and gait disturbance

    Fatigue

    Disturbances of brain stem function

    Perturbations of nerve conduction

    Cognition

    Visual symptoms

    Rehabilitation in multiple sclerosis

    Summary


    18. Disease modifying treatments in multiple sclerosis

    The aims of disease modifying treatment

    The principles of evidence based prescribing in multiple sclerosis

    The role of magnetic resonance imaging in clinical trials

    Drugs that stimulate the immune response

    Drugs that non-specifically suppress the immune response

    The beta interferons

    Molecules that inhibit T cell-peptide binding

    Specific treatments that target T cells

    Agents which inhibit macrophages and their mediators

    Recent miscellaneous treatments

    Postscript


    19: The person with multiple sclerosis: present and future

    Empirical versus hypothesis driven therapeutics

    New opportunities for immunological intervention

    Axon protection; acute and chronic

    Treatment in special situations

    Remyelination:


    Index

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