Mandell, Douglas, and Bennett

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases

Expert Consult Premium Edition - Enhanced Online Features and Print

After thirty years, PPID is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. Mandell, Bennett, and Dolin have substantially revised and meticulously updated, this new edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 7th Edition helps you identify and treat whatever infectious disease you see. And, as an Expert Consult title with enhanced online features, this updated 7th edition comes with convenient access to the full text online, regular updates on the new developments in the field and advances in therapy, and more at

Infectious Disease


Published: September 2009

Imprint: Churchill Livingstone

ISBN: 978-1-4557-0872-7


  • Part I Basic Principles in the Diagnosis and Management of Infectious Diseases

    Section A. Microbial Pathogenesis

    1 A Molecular Perspective of Microbial Pathogenicity
    2 Microbial Adherence
    3 Toxins

    Section B. Host Defense Mechanisms

    4 Innate (General or Nonspecific) Host Defense Mechanisms
    5 Human Genetics and Infection
    6 Antibodies
    7 Complement
    8 Granulocytic Phagocytes
    9 Cell-Mediated Defense Against Infection
    10 Nutrition, Immunity, and Infection
    11 Probiotics
    12 Evaluation of the Patient with Suspected Immunodeficiency

    Section C. Epidemiology of Infectious Diseases

    13 Epidemiologic Principles
    14 Outbreak Investigation
    15 Emerging and Reemerging Infectious Disease Threats
    16 Hospital Preparedness for Emerging and Highly Contagious Infectious Diseases

    Section D. Clinical Microbiology

    17 The Clinician and the Microbiology Laboratory

    Section E. Anti-Infective Therapy

    18 Principles of Anti-infective Therapy
    19 Molecular Mechanisms of Antibiotic Resistance in Bacteria
    20 Pharmacokinetics and Pharmacodynamics of Anti-infective Agents
    21 Penicillins
    22 Cephalosporins
    23 Other â-Lactam Antibiotics
    24 â-Lactam Allergy
    25 Fusidic Acid
    26 Aminoglycosides
    27 Tetracyclines and Chloramphenicol
    28 Rifamycins
    29 Metronidazole
    30 Macrolides, Clindamycin, and Ketolides
    31 Glycopeptides, Streptogramins, and Lipopeptides
    32 Polymyxins (Polymyxin B and Colistin)
    33 Oxazolidinones
    34 Sulfonamides and Trimethoprim
    35 Quinolones
    36 Unique Antibacterial Agents
    37 Urinary Tract Agents: Nitrofurantoin and Methenamine
    38 Topical Antibacterials
    39 Antimycobacterial Agents
    40 Antifungal Agents
    41 Antiviral Drugs (Other Than Antiretrovirals)
    42 Immunomodulators
    43 Hyperbaric Oxygen
    44 Agents Active against Parasites and Pneumocystis
    45 Complementary and Alternative Medicines for Infectious Diseases
    46 Antimicrobial Management: Cost and Resistance
    47 Interpretation of Clinical Trials of Antimicrobial Agents
    48 Outpatient Parenteral Antimicrobial Therapy
    49 Tables of Antimicrobial Agent Pharmacology

    Part II Major Clinical Syndromes

    Section A. Fever

    50 Temperature Regulation and the Pathogenesis of Fever
    51 Fever of Unknown Origin
    52 The Acutely Ill Patient with Fever and Rash

    Section B. Upper Respiratory Tract Infections

    53 The Common Cold
    54 Pharyngitis
    55 Actue Laryngitis
    56 Acute Laryngotracheobronchitis (Croup)
    57 Otitis Externa, Otitis Media, and Mastoiditis
    58 Sinusitis
    59 Epiglottitis
    60 Infections of the Oral Cavity, Neck, and Head

    Section C. Pleuropulmonary and Bronchial Infections

    61 Acute Bronchitis
    62 COPD, Chronic Bronchitis, and Acute Exacerbations
    63 Bronchiolitis
    64 Acute Pneumonia
    65 Empyema and Pleural Effusion
    66 Lung Abscess
    67 Chronic Pneumonia
    68 Cystic Fibrosis

    Section D. Urinary Tract Infections

    69 Urinary Tract Infections

    Section E. Sepsis

    70 Sepsis, Severe Sepsis, and Septic Shock

    Section F. Intra-abdominal Infection

    71 Peritonitis and Intraperitoneal Abscesses
    72 Infections of the Liver and Biliary System
    73 Pancreatic Infections
    74 Splenic Abscess
    75 Appendicitis
    76 Diverticulitis and Typhlitis

    Section G. Cardiovascular Infections

    77 Endocarditis and Intravascular Infections
    78 Prosthetic Valve Endocarditis
    79 Infections of Non-Valvular Cardiovascular Devices
    80 Prophylaxis of Infective Endocarditis
    81 Myocarditis and Pericarditis
    82 Mediastinitis

    Section H. Central Nervous System Infections

    83 Approach to the Patient with Central Nervous System Infection
    84 Acute Meningitis
    85 Infections of CSF Shunts
    86 Chronic Meningitis
    87 Encephalitis, Myelitis, and Neuritis
    88 Brain Abscess
    89 Subdural Empyema, Epidural Abscess, and Intracranial Suppurative Thrombophlebitis

    Section I. Skin and Soft Tissue Infections

    90 Cellulitis, Necrotizing Fasciitis and Subcutaneous Tissue Infections
    91 Myositis
    92 Lymphadenitis and Lymphangitis

    Section J. Gastrointestinal Infections and Food Poisoning

    93 Principles and Syndromes of Enteric Infection
    94 Esophagitis
    95 Nausea, Vomiting, and Noninflammatory Diarrhea
    96 Antibiotic-Associated Colitis
    97 Inflammatory Enteritides
    98 Enteric Fever and Other Causes of Abdominal Symptoms with Fever
    99 Foodborne Disease
    100 Tropical Sprue/Enteropathy
    101 Whipple's Disease

    Section K. Bone and Joint Infections

    102 Infectious Arthritis
    103 Osteomyelitis
    104 Infections in Prostheses in Bones and Joints

    Secction L. Diseases of the Reproductive Organs and Sexually Transmitted Diseases

    105 Genital Skin and Mucous Membrane Lesions
    106 Urethritis
    107 Vulvovaginitis and Cervicitis
    108 Infections of the Female Pelvis
    109 Prostatitis, Epididymitis, and Orchitis

    Section M. Eye Infections

    110 Microbial Conjunctivitis
    111 Microbial Keratitis
    112 Endophthalmitis
    113 Infectious Causes of Uveitis
    114 Periocular Infections

    Section N. Hepatitis

    115 Acutel Hepatitis
    116 Chronic Viral Hepatitis

    Section O. Acquired Immunodeficiency Syndrome

    117 Global Perspectives on HIV Infection and Acquired Immunodeficiency Syndrome
    118 Epidemiology and Prevention of AIDS and HIV Infection
    119 Diagnosis of Human Immunodeficiency Virus Infection
    120 The Immunology of Human Immunodeficiency Virus Infection
    121 General Clinical Manifestations of Human Immunodeficiency Virus Infection
    122 Pulmonary Manifestations of Human Immunodeficiency Virus Infection
    123 GI and Hepatobiliary Manifestations of Human Immunodeficiency Virus Infection
    124 Neurologic Diseases Caused by HIV-1 and Opportunistic Infections
    125 Malignancies in Human Immunodeficiency Virus Infection
    126 Human Immunodeficiency Virus Infection in Women
    127 Pediatric Human Immunodeficiency Virus Infection
    128 Antiretroviral Therapy for Human Immunodeficiency Virus Infection
    129 Management of Opportunistic Infections Associated with HIV Infection
    130 Vaccines for Human Immunodeficiency Virus-1 Infection

    Section P. Miscellaneous Syndromes

    131 Chronic Fatigue Syndrome

    Part III Infectious Diseases and Their Etiologic Agents

    Section A. Viral Diseases

    132 Introduction to Viruses and Viral Diseases - DNA Viruses - Poxviridae
    133 Orthopoxviruses: Vaccinia, Variola, Monkeypox, and Cowpox
    134 Other Poxviruses: Parapoxviruses, Molluscum Contagiosum, and Tanapox Herpesviridae
    135 Introduction to Herpesviridae
    136 Herpes Simplex Virus
    137 Varicella-Zoster Virus
    138 Cytomegalovirus
    139 Epstein-Barr Virus (Infectious Mononucleosis)
    140 Human Herpesvirus Types 6 and 7
    141 Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus Type 8)
    142 Herpes B Virus - Adenoviridae
    143 Adenovirus - Papovaviridae
    144 Papillomaviruses
    145 JC, BK, and Other Polyomaviruses; Progressive Multifocal Leukoencephalopathy - Hepadnaviridae
    146 Hepatitis B Virus and Hepatitis Delta Virus - Parvoviridae
    147 Human Parvoviruses - RNA Viruses - Reoviridae
    148 Orthoreoviruses and Orbiviruses
    149 Coltiviruses and Seadornaviruses (Colorado Tick Fever)
    150 Rotaviruses - Togaviridae
    151 Alphaviruses
    152 Rubella Virus (German Measles) - Flaviviruses
    153 Flaviviruses (Yellow Fever, Dengue, Dengue Hemorrhagic Fever, Japanese Encephalitis, West Nile Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis)
    154 Hepatitis C - Coronaviridae
    155 Coronaviruses, Including SARS-Associated Coronavirus
    156 Parainfluenza Viruses
    157 Mumps Virus
    158 Respiratory Syncytial Virus
    159 Human Metapneumovirus
    160 Measles Virus (Rubeola)
    161 Zoonotic Paramyxoviruses: Hendra, Nipah, and Menangle Viruses
    162 Vesicular Stomatitis Virus and Related Viruses
    163 Rhabdoviruses - Filoviridae
    164 Marburg and Ebola Virus Hemorrhagic Fevers - Orthomyxoviridae
    165 Influenza Viruses Including Avian Influenza - Bunyaviridae
    166 California Encephalitis, Hantavirus Pulmonary Syndrome, and Bunyavirid Hemorrhagic Fevers - Arenaviridae
    167 Lymphocytic Choriomeningitis Virus, Lassa Virus, and the South American Hemorrhagic Fevers - Retroviridae
    168 Human T-Cell Lymphotropic Virus Types I and II
    169 Human Immunodeficiency Viruses - Picornaviridae
    170 Introduction to the Enteroviruses
    171 Poliovirus
    172 Coxsackieviruses, Echoviruses, and Newer Enteroviruses
    173 Hepatitis A Virus - Caliciviridae and Other Gastrointestinal Viruses
    174 Rhinovirus
    175 Noroviruses and Other Caliciviruses
    176 Astroviruses and Picobirnaviruses - Unclassified Viruses
    177 Hepatitis E Virus

    Section B. Prion Diseases

    178 Prions and Prion Diseases of the Central Nervous System (Transmissible Neurodegenerative Diseases)

    Section C. Chlamydial Diseases

    179 Introduction to Chlamydial Diseases
    180 Chlamydia trachomatis (Trachoma, Perinatal Infections, Lymphogranuloma Venereum, and Other Genital Infections)
    181 Chlamydophila (Chlamydia) psittaci (Psittacosis)
    182 Chlamydophila (Chlamydia) pneumoniae
    183 Introduction to Mycoplasma Diseases
    184 Mycoplasma pneumoniae and Atypical Pneumonia

    Section D. Mycoplasma Diseases

    185 Genital Mycoplasmas: Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma Species

    Section E. Rickettsioses, Ehrlichioses, and Anaplasmosis

    186 Introduction to Rickettsioses, Ehrlichioses and Anaplasmosis
    187 Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)
    188 Rickettsia akari (Rickettsialpox)
    189 Coxiella burnetii (Q Fever)
    190 Rickettsia prowazekii (Epidemic or Louse-Borne Typhus)
    191 Rickettsia typhi (Murine Typhus)
    192 Orientia Tsutsugamushi
    193 Ehrlichia Chaffeensis and Ehrlichia Phagocytophila

    Section F. Bacterial Diseases

    194 Introduction to Bacteria and Bacterial Diseases - Gram-Positive Cocci
    195 Staphylococcus aureus (Including Staphylococcal Toxic Shock)
    196 Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci
    197 Classification of Streptococci
    198 Streptococcus pyogenes
    199 Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis
    200 Streptococcus pneumoniae
    201 Enterococcus Species, Streptococcus bovis, and Leuconostoc Species
    202 Streptococcus agalactiae (Group B Streptococcus)
    203 Viridans Streptococci, Groups C and G Streptococci, and Gemella morbillorum
    204 Streptococcus anginosus Group - Gram-Positive Bacilli
    205 Corynebacterium diphtheriae
    206 Corynebacteria other than Diphtheria and Rhodococcus
    207 Listeria monocytogenes
    208 Bacillus anthracis (Anthrax)
    209 Bacillus Species and Other than Bacillus anthracis
    210 Erysipelothrix rhusiopathiae - Gram-Negative Cocci
    211 Neisseria meningitidis
    212 Neisseria gonorrhoeae
    213 Moraxella catarrhalis and Other Gram-Negative Cocci - Gram-Negative Bacilli
    214 Vibrio cholerae
    215 Other Pathogenic Vibrios
    216 Campylobacter jejuni and Related Species
    217 Helicobacter pylori and Other Gastric Helicobacter Species
    218 Enterobacteriaceae
    219 Pseudomonas species, including Ps. aeruginosa
    220 Stenotrophomonas maltophilia and Burkholderia cepacia complex
    221 Burkholderia pseudomallei and Burkholderia mallei
    222 Acinetobacter Species
    223 Salmonella Species, Including Salmonella typhi
    224 Shigella Species (Bacillary Dysentery)
    225 Haemophilus species (incluing H. influenzae and chancroid)
    226 Brucella Species
    227 Francisella tularensis (Tularemia)
    228 Pasteurella Species
    229 Yersinia Species, Including Plague
    230 Bordetella Pertussis
    231 Rat-Bite Fever Streptobacillus moniliformis and Spirillum minus
    232 Legionella
    233 Other Legionella Species
    234 Capnocytophaga
    235 Bartonella, Including Cat-Scratch Disease
    236 Calymmatobacterium granulomatis (Donovanosis, Granuloma Inguinale)
    237 Other Gram-Negative and Gram-Variable Bacilli - Spirochetes
    238 Treponema pallidum (Syphilis)
    239 Endemic Treponematoses
    240 Leptospira Species (leptospirosis)
    241 Borrelia Species (Relapsing Fever)
    242 Borrelia burgdorferi (Lyme Disease, Lyme Borreliosis) - Anaerobic Bacteria
    243 Anaerobic Infections: General Concepts
    244 Clostridium tetani (Tetanus)
    245 Clostridium botulinum (Botulism)
    246 Gas Gangrene and Other Clostridium-Associated Diseases
    247 Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species
    248 Anaerobic Cocci; Anaerobic
    249 Anaerobic Gram-Positive Non-sporulating Bacilli - Mycobacterial Diseases
    250 Mycobacterium tuberculosis
    251 Mycobacterium leprae
    252 Mycobacterium Avium-intracellulare
    253 Infections due to Mycobacteria other than M. tuberculosis and M. Avium Complex -Higher Bacterial Diseases
    254 Nocardia Species
    255 Agents of Actinomycosis

    Section G. Mycoses

    256 Introduction to Mycoses
    257 Candida Species
    258 Aspergillus Species
    259 Agents of Mucormycosis
    260 Sporothrix schenckii
    261 Agents of Chromomycosis
    262 Agents of Mycetoma
    263 Cryptococcus neoformans
    264 Histoplasma capsulatum
    265 Blastomyces dermatitidis
    266 Coccidioides Species
    267 Dermatophytosis and Other Superficial Mycoses
    268 Paracoccidioides brasiliensis
    269 Uncommon Fungi and Prototheca
    270 Pneumocystis
    271 Microsporidiosis

    Section H. Protozoal Diseases

    272 Introduction to Protozoal Diseases
    273 Entamoeba species including amoebiasis
    274 Free-Living Amebas
    275 Plasmodium Species (Malaria)
    276 Leishmania Species: Visceral, Cutaneous, and Mucocutaneous Leishmaniasis
    277 Biology of Trypanosoma Species
    278 Agents of African Trypanosomiasis (Sleeping Sickness)
    279 Toxoplasma gondii
    280 Giardia lamblia
    281 Trichomonas vaginalis
    282 Babesia Species
    283 Cryptosporidium Species
    284 Isospora belli, Sarcocystis Species, Blastocystis hominis and Cyclospora

    Section I. Diseases Due to Toxic Algae

    285 Human Illness Associated with Harmful Algal Blooms

    Section J. Diseases Due to Helminths

    286 Introduction to Helminth Infections
    287 Intestinal Nematodes (Roundworms)
    288 Tissue Nematodes, Including Trichinosis, Dracunculiasis, and the Filariases
    289 Trematodes (Schistosomes and Other Flukes)
    290 Cestodes (Tapeworms)
    291 Visceral Larva Migrans and Other Unusual Helminth Infections

    Section K. Ectoparasitic Diseases

    292 Introduction to Ectoparasitic Diseases
    293 Lice (Pediculosis)
    294 Scabies
    295 Myiasis and Tungiasis
    296 Mites (Including Chiggers)
    297 Ticks (Including Tick Paralysis)

    Section L. Diseases of Unknown Etiology

    298 Kawasaki Syndrome

    Part IV Special Problems

    Section A. Nosocominal Infections

    299 Organization for Infection Control
    300 Isolation
    301 Disinfection, Sterilization, and Control of Hospital Waste
    302 Infections Caused by Percutaneous Intravascular Devices
    303 Nosocomial Pneumonia
    304 Nosocomial Urinary Tract Infections
    305 Nosocomial Hepatitis and Other Infections Transmitted by Blood and Blood Products
    306 Human Immunodeficiency Virus in Health Care Settings
    307 Nosocomial Herpesvirus Infections

    Section B. Infections in Special Hosts

    308 Infections in the Immunocompromised Host: General Principles
    309 Prophylaxis and Empirical Therapy of Infection in Cancer Patients
    310 Risk Factors and Approaches to Infections in Transplant Recipients
    311 Infections in Hematopoietic Stem Cell Transplant Recipients
    312 Infections in Solid Organ Transplant Recipients
    313 Infections in Patients with Spinal Cord Injury
    314 Infections in the Elderly
    315 Infections in Asplenic Patients
    316 Infections in Injection Drug Users
    317 Postoperative Infections and Antimicrobial Prophylaxis

    Section C. Surgical and Trauma-Related Infections

    318 Infections in Patients with Burns
    319 Bites

    Section D. Immunization

    320 Immunization

    Section E. Biodefense

    321 Bioterrorism: An Overview
    322 Plague as Bioterrorism Weapon
    323 Tularemia as a Bioterrorism Weapon
    324 Smallpox as an Agent of Bioterrorism
    325 Anthrax as an Agent of Bioterrorism
    326 Botulinum Toxin as an Agent of Bioterrorism
    327 Viral Hemorrhagic Fevers as Agents of Bioterrorism

    Section F. Zoonoses

    328 Zoonoses
    Section G. Protection of Travelers
    329 Protection of Travelers
    330 Infections in Returning Travelers


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