This issue of the Neurosurgery Clinics, Malignant Tumors of the Skull Base, is Guest Edited by Drs. Orin Bloch and Franco DeMonte. Malignant tumors of the skull base pose significant challenges to the clinician, because of their proximity to critical neurovascular structures. This issue will explore various approaches to the removal of malignant tumors of the skull base, including open surgical approaches and minimally invasive approaches. Other articles in this issue include topics such as craniofacial reconstruction following oncologic resection, temporal bone malignancies, sinonasal carcinomas, and radiotherapy for malignant skull base tumors.