Magnetic Resonance Spectroscopy

Tools for Neuroscience Research and Emerging Clinical Applications

Edited by

  • Charlotte Stagg, St Edmund Hall, University of Oxford, Oxford, United Kingdom
  • Douglas Rothman, Yale University School of Medicine, New Haven, CT, United States

Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications is the first comprehensive book for non-physicists that addresses the emerging and exciting technique of magnetic resonance spectroscopy. Divided into three sections, this book provides coverage of the key areas of concern for researchers. The first, on how MRS is acquired, provides a comprehensive overview of the techniques, analysis, and pitfalls encountered in MRS; the second, on what can be seen by MRS, provides essential background physiology and biochemistry on the major metabolites studied; the final sections, on why MRS is used, constitutes a detailed guide to the major clinical and scientific uses of MRS, the current state of teh art, and recent innovations.

Magnetic Resonance Spectroscopy will become the essential guide for people new to the technique and give those more familiar with MRS a new perspective.

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Neuroscience researchers and clinicians (neurologists, radiologists, psychiatrists) using MR imaging


Book information

  • Published: December 2013
  • ISBN: 978-0-12-401688-0

Table of Contents

Section 1: Technical Aspects - How MRS Is Acquired
1.1 Basis of Magnetic Resonance
1.2 Localized Single-Voxel Magnetic Resonance Spectroscopy, Water Suppression, and Novel Approaches for Ultrashort Echo-Time Measurements
1.3 Technical considerations for Multivoxel Approaches and Magnetic Resonance Spectroscopic Imaging
1.4 Spectral Editing and 2D NMR
1.5 Spectral Quantification and Pitfalls in Interpreting Magnetic Resonance Spectroscopic Data: What to Look Out For

Section 2: Biochemistry - What Underlies the Signal?
2.1 N-Acetylaspartate and N-Acetylaspartylglutamate in Central Nervous System Health and Disease
2.2 The Biochemistry of Creatine
2.3 The Biochemistry of Choline
2.4 Glutamate
2.5 Other Significant Metabolites: Myo-Inositol, GABA, Glutamine, and Lactate

Section 3: Applications of Proton-MRS
3.1 Usefulness of Proton Magnetic Resonance Spectroscopy in the Clinical Management of Brain Tumors
3.2 Multiple Sclerosis and Inflammatory Diseases
3.3 Epilepsy
3.4 Stroke and Cerebral Ischaemia
3.5 Use of MRS in Inborn Errors of Metabolism: Canavan’s Disease and MRS in Differential Diagnosis
3.6 MRS of Psychiatric Disorders
3.7 Preclinical and Clinical Applications of 1H-MRS in the Spinal Cord
3.8 Interindividual Differences in Behavior and Plasticity
3.9 MRS in Development and Across the Lifespan
3.10 Hormonal Influences on Magnetic Resonance Spectroscopy Measures
3.11 Magnetic Resonance Spectroscopy in Neuroenergetics and Neurotransmission

Section 4: Applications of Non-Proton MRS
4.1 Quantitative Metabolic Magnetic Resonance Imaging of Sodium, Oxygen, Phosphorus, and Potassium in the Human Brain: A Rationale for Bioscales in Clinical Applications
4.2 Carbon (13C) MRS
4.3 Hyperpolarized Magnetic Resonance Imaging and Spectroscopy of the Brain