Edited by

  • G. van der Vusse, Department of Physiology, Maastricht University, The Netherlands

This volume on lipobiology contains 27 chapters dealing with a selected number of subjects of lipid homeostasis in the eukaryotic cells and mammalian body. It focuses on subjects in the field of lipobiology characterised by new insights in underlying regulatory mechanisms. Special attention is paid to proteins involved in lipid transfer and enzymes in lipid metabolism and the regulation of expression of genes encoding for lipid handling proteins.
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Book information

  • Published: February 2004
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-51496-7

Table of Contents

1. Introduction: Brief overview on the volume on lipobiology (G.J. van der Vusse). 2. Intestinal uptake and transport of fatty acid (P. Besnard). 3. Plasma albumin as fatty acid carrier (S. Curry). 4. Cellular uptake of long chain free fatty acids (P. Berk). 5. Role of FATP in parenchymal cell fatty acid uptake (W. Stremmel). 6. Uptake of fatty acids by parenchymal cells: role of FAT/CD36 (J.F.C. Glatz). 7. Properties and physiological significance of fatty acid binding proteins (F. Spener). 8. Long chain acyl-CoA esters and acyl-CoA binding protein (ACBP) in cell function (J. Knudsen). 9. Physical aspects of fatty acid transport between and through biological membranes (J.A. Hamilton). 10. Computational modeling of cardiac fatty acid uptake and utilization (M. Musters). 11. Regulation of fatty acid oxidation by Malonyl CoA in cardiac muscle (G. Lopaschuk). 12. Alterations in muscular fatty acid handling in diabetes (J. Luiken). 13. Fatty acid metabolism in cardiac hypertrophy and failure (H. Taegtmeyer). 14. Physiological significance of uncoupling proteins-3; a role in fatty acid handling? (P. Schrauwen). 15. Defects in mitochondrial and peroxisomal fatty acid oxidation (R.J.A. Wanders). 16. Transcriptional regulation of cellular fatty acid homeostasis (M. van Bilsen). 17. Triacylglycerol metabolism in adipose tissue (K. Frayn). 18. Phospholipid biosynthesis in lipobiology (D. Choy). 19. Membrane phospholipid asymmetry (E.M. Bevers, P. Comfurius, R.F.A. Zwaal). 20. Regulation of cPLA2 activity. 21. Mammalian phospholipase C (M. Schmidt). 22. Mammalian phospholipase D - properties and regulation (J.H. Exton). 23. Metabolism and physiological functions of sphingolipids (J. Ohanian). 24. Essential fatty acid metabolism during pregnancy and early human development (G. Hornstra). 25. Phospholipid transfer protein and atherosclerosis (R. de Crom). 26. PPAR and atherosclerosis (B. Staels). 27. The role of the steroidogenic acute regulatory (StAR) protein in intramitochondrial cholesterol transfer and steroidogenesis (D.M. Stocco).