Linkage Thermodynamics of Macromolecular Interactions
- Enrico Di Cera, Washington University School of Medicine, St. Louis, Missouri, U.S.A.
- Frederic Richards, Yale University, New Haven, Connecticut, U.S.A.
- David Eisenberg, University of California, Los Angeles, U.S.A.
- Peter Kim, Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Howard Hughes Medical Institute Research Laboratories, Cambridge, U.S.A.
This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.
Biochemists, molecular biologists, biophysicists, and biomedical researchers.