Life and Death in the Nervous System

Role of Neurotrophic Factors and their Receptors

Edited by

  • C.F. Ibáñez, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
  • T. Hökfelt
  • L. Olson
  • K. Fuxe
  • H. Jörnvall, Department of Neuroscience, Karolinska Institute, Doktorsringen 12, S-171 77 Stockholm, Sweden
  • D. Ottoson, IBRO Secretariat, 51 Bd de Montmorency, F-75016, Paris, France

In multicellular organisms, survival, proliferation and differentiation of a given cell depend upon signals produced by other cells, resulting in the coordinated development and function of the various tissues and organs. In the nervous system, the social control of cell survival and differentiation is achieved through the action of distinct groups of polypeptides collectively known as neurotrophic factors. Through the study of nerve growth factor (NGF), the other members of the neurotrophin family and other neurotrophic molecules, we have begun to understand the mechanisms that govern life and death in the nervous system. The collection of chapters in this book offers a comprehensive view of the state-of-the-art in one of the fastest growing fields of neuroscience. From the details of their atomic structure, to the devastating consequences of gene ablation, these pages summarize our current knowledge on neurotrophic factors and their receptors derived from new techniques in molecular biology, cell biology and genetics.
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For neuroscientists, neuropathologists, neurologists, neurophysiologists and neurogeneticists.


Book information

  • Published: December 1995
  • Imprint: PERGAMON
  • ISBN: 978-0-08-042527-6


This is a comprehensive review of one of the fastest growing fields in the neurosciences.... Molecular biologists working in the neurosciences will find this book of considerable interest.
Aslib Book Guide, May 1996

Table of Contents

Preface. A memorial Symposium for Håkan Persson (L. Philipson). List of Contributors. Structure-Function Relationships and Mechanisms of Action of Neurotrophic Factors. Insights into neurotrophic factor function from structural analyses (N.Q. McDonald, J. Murray-Rust). Functional analysis of receptor binding determinants in the neurotrophin family (C.F. Ibáñez et al.). Signal transduction by Trk receptors (D.R. Kaplan). On the mechanisms by which neurotrophic factors regulate neuronal survival and cell death (L.A. Greene et al.). Neurotrophic Factor Receptors: Expression and Function. The interaction between the two receptors for NGF, p75 LNTR and TrkA (P.A. Barker, E.M. Shooter). Interactions between NGF receptors, TrkA and p75 (M.V. Chao, L.J. Hubert). Receptors and signaling pathways used by the neurotrophins, CNTF and a new family of neurotrophic factors, the EFLs (G.D. Yancopoulos). Embryonic expression of neurotrophin (TrkA) receptor mRNAs within sensory neurons: chicken development as a model (R. Williams et al.). Development: Proliferation and Differentiation. Brain-derived neurotrophic factor and the developing chick retina (A. Cellerino et al.). Neurotrophins in the developing avian visual system (F. Hallböök et al.). The regulation and function of NGF receptors in normal and immortalized sympathoadrenal progenitor cells (J.M. Verdi et al.). Sequential trophic regulation of sympathetic neuroblast development by NT-3 and NGF (I.B. Black et al.). Effects of Brain–Derived neurotrophic factor and neurotrophin-4 on embryonic rat sensory neurons (H. Paves et al.). Role of neurotrophic factors in cerebellar development (D. Lindholm et al.). Neurotrophins, depolarization, and second messengers interact to control serotonergic neuronal differentiation (S.R. Whittemore et al.). Control of Neurotrophic Factor Synthesis and Release. Structure and regulation of BDNF and NT-4 genes (M. Metsis et al.). Neurotrophins as mediators of neuronal plasticity (A. Blöchl et al.). Stimulation of neurotrophic factor expression: links to different forms of brain plasticity (C.M. Gall et al.). Molecular determinants of neurotrophin actions in the brain (W.J. Friedman et al.). Gene Knock-Outs. Neurotrophins: essential functions in vivo characterized by targeted gene mutations (L.F. Reichardt et al.). Requirement for neurotrophin-3 in development of the muscle proprioceptive system (P. Ernfors et al.). Life and death in mice without Trk neurotrophin receptors (M. Barbacid). Neurotrophic Factor Function In Vivo: Degeneration and Regeneration. Specificity, synergy and autocrine roles of the neurotrophins and CNTF (R.M. Lindsay). Therapeutic use of neurotrophic factors (F. Hefti et al.). NGF-dependent regeneration of adult septal cholinergic axons into denervated hippocampus (F.H. Gage et al.). Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo (B.J. Hoffer et al.). Neurotrophins in kindling epilepsy: neuronal protection or induction of sprouting and epileptogenesis? (O. Lindvall et al.). Concluding Remarks. Future directions and clinical implications of neurotrophic factor research (L. Olson). Håkan Persson's Publication List. Index.

55 illus., 50 line drawings.