Lead and Public Health book cover

Lead and Public Health

Science, Risk and Regulation

The book presents a detailed assessment of the health science of lead and the human health risk assessment models for lead’s human health impacts, followed by an account of various regulatory efforts in the United States and elsewhere to eliminate or reduce human toxic exposures to lead. The science of lead as presented here covers releases of lead into the environment, lead’s movement through the environment to reach humans who are then exposed, and the spectrum of toxic effects, particularly low-level toxic effects, on the developing central nervous system of the very young child. The section on human health risk assessment deals with quantifying not only the dose-response relationships that underlie toxic responses to lead in sensitive populations but also with the likelihood of toxic responses vis-à-vis environmental lead at some level of exposure. This section includes a treatment of computer models of lead exposure, particularly those that use lead in whole blood as a key measure. Various models convert lead intake via various body compartments into measures of body lead burden. Such measures are then directly related to severity of injury.

The final section of the book deals with past and present regulatory efforts to control lead releases into the human environment. Current control efforts present a mixed picture. The most problematic issue is the continued presence of lead paint in older housing and lead in soils of urban and mining industry communities.

Audience

Environmental and regulatory personnel, law firms with practices that cover lead poisoning, the U.S. Environmental Protection Agency, all state Superfund offices, public health offices

Hardbound, 950 Pages

Published: August 2011

Imprint: Elsevier

ISBN: 978-0-444-51554-4

Contents

  • Chapter 1: Introduction
    Chapter 2: A Brief Early History of Lead as an Evolving Global Pollutant and Toxicant
     Chapter 3: Lead in the Human Environment: Production, Uses, Trends
    Chapter 4: Lead in the Human Environment: Lead Emissions and Emission Trends
    Chapter 5: Lead in the Human Environment: Fate and Transport Processes
    Chapter 6: Lead Concentrations in Environmental Media Relevant to Human Lead Exposures
    Chapter 7: Lead Exposure in Human Populations: Lead Intakes
    Chapter 8: Lead Exposure in Human Populations: Lead Toxicokinetics and Biomarkers of Lead Exposure
    Chapter 9: Predictive Modeling Approaches for Assessing Human Lead Exposure
    Chapter 10: The Environmental Epidemiology of Human Lead Exposure
    Chapter 11: Lead Toxicity in Humans: a Brief Historical Perspective and Public Health
    Chapter 12: Neurotoxicity of Lead in Human Populations
    Chapter 13: Cardiovascular Toxicity of Lead in Human Populations
    Chapter 14: Reproductive and Developmental Toxicity of Lead in Human Populations
    Chapter 15: The Nephrotoxicity of Lead in Human Populations
    Chapter 16: Hematological Effects of Lead in Human Populations
    Chapter 17: Carcinogenic and Genotoxic Effects of Lead in Human Populations
    Chapter 18: Immunotoxic Effects of Lead in Human Populations
    Chapter 19: Effects of Lead on Other Organs and Systems in Human Populations
    Chapter 20: Human Health Risk Assessment for Lead: Introduction, Context, Rationale
    Chapter 21: Hazard Characterization for Lead in Human Populations
    Chapter 22: Dose-Response Relationships for Toxic Effects of Lead in Human Populations
    Chapter 23: Exposure Characterizations for Lead in Specific Human Populations
    Chapter 24: Health Risk Characterization of Lead Effects in Human Populations
    Chapter 25: Legislative Aspects of Lead Regulation and Regulatory Policies
    Chapter 26: Lead Regulation and Regulatory Policies: Lead in Paint
    Chapter 27: Regulation and Regulatory Policies for Lead in Ambient Air
    Chapter 28: Regulation and Regulatory Policies for Lead in Water
    Chapter 29: Regulation and Regulatory Policies for Lead in Food

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