Interleukin-1 in the Brain
- N.J. Rothwell, Department of Physiological Sciences, University of Manchester School of Biological Sciences, Stopford Building, Oxford Road, Manchester M13 9PT, UK
- R.D. Dantzer, INSERM U176, Rue Camille Saint-Saens, 33077 Bordeaux Cedex, France
Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors. The main part of the book examines the different neural effects of IL-1 and the mechanisms which are involved in these actions, comparing IL-1 where possible to other inflammatory cytokines which also have neurotrophic effects. The final section evaluates the possible role of IL-1 in neural plasticity and neuronal degeneration.View full description
For neurobiologists and all those with an interest in cytokines in general and interleukin-1 in particular.
- Published: October 1992
- Imprint: PERGAMON
- ISBN: 978-0-08-041996-1
The quality of the chapters is generally very good, and each contains a rather extensive reference list that would be of use to anyone with an active interest in the field...provides a single-source overview of the field.
Emmett T. Cunningham, Immunology Today
Certainly, the editors did not mean to compile extensive reviews but rather set some highlights touching on major aspects in this field of research and encouraging the interested reader to dig for more details in specialized journals. This "appetite" is nourished, in particular, by the smart combination of reviews decorated with a few recent results from each contributors' own laboratories. In this way, it was possible to reasonably price the book and make it appealing for both the interested scientist and the insider. It is another milestone in the successful series of Pergamon studies in neuroscience.Peter J. Gebicke-Haerter, Neurochemistry International
Table of ContentsForeword. Location of interleukin-1 in the nervous system, M. Schultzberg. Brain interleukin-1 receptors: mapping, characterization and modulation, F. Haour et al. Interleukin-1&Bgr; activation of the central nervous system, P. E. Gottschall et al. Electrophysiological studies of the effects of Interleukin-1 and &agr;-interferon on the EEG and pituitary-adrenocortical activity, D. Saphier. The immune-hypothalamo-pituitary adrenal axis: its role in immunoregulation and tolerance to self-antigens, F. Berkenbosch et al. The pyrogenic action of cytokines, C. M. Blatteis. Metabolic responses to interleukin-1, N. J. Rothwell. Behavioural effects of cytokines, R. Dantzer et al. Interleukin-1 involvement in the regulation of sleep, M. R. Opp & J. M. Krueger. Regulation of the synthesis of nerve growth factor (NGF) by interleukin-1 (IL-1): facts and questions, M. Meyer et al. Cytokines and neuronal degeneration, E. E. Wollman et al. Index.