Intercellular Signaling in Development and Disease book cover

Intercellular Signaling in Development and Disease

Cell Signaling Collection

Required reading for anyone involved in cell signaling research with articles written and edited by experts in the field. This title covers disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, andinflammatory bowel disease, along with up-to-date research on signaling systems and mutations in
transcription factors that provide new targets for treating disease.


Professionals, researchers and graduate students in molecular biology, biochemistry, cell biology, biomedicine, structural biology, systems biology, and genetics.

Paperback, 540 Pages

Published: April 2011

Imprint: Academic Press

ISBN: 978-0-12-382215-4


  • "The Cell Signaling Collection consists of four independent volumes which reprint articles from the second edition of the </Handbook of Cell Signaling/> carefully selected to alert medical and biological scientists to recent developments in the study of cellular signaling. This volume contains 57 articles exploring transduction mechanisms. After an overview of intracellular signaling, they cover phosporylation and dephosphorylation in kinases and phosphates, lipid signaling, cyclic nucleotides, and G proteins. The other volumes cover the functioning of transmembrane receptors, the regulation of organelle and cell compartment signaling, and intracellular signaling in development and disease."--Reference and Research Book News

    "For professionals, graduate researchers, and graduate students in biochemistry, biology, genetics, and biomedicine, Dennis (chemistry and biochemistry and pharmacology, U. of California, San Diego) and Bradshaw (chemistry and pharmaceutical chemistry, U. of California, San Francisco) bring together 52 articles from the authors' </Handbook of Cell Signaling/> on cell-cell signaling, signaling development, and signaling in disease. A group of biologists, chemists, oncologists, surgeons, and other scientists from the US, Europe, Singapore, and Australia emphasize the role of cell-cell interaction and organ and tissue effects in signaling activities and their disease implications. They do not cover other aspects of cell signaling like transmembrane receptor structure, receptor organization and function, intracellular signaling mechanisms, and transcriptional activation and responses in other organelles."--Reference and Research Book News


  • The fourth volume includes chapters 294 to 340

    Signaling From Intracellular Compartments

    294 . Protein Quality Control in the Endoplasmic Reticulum

    295 . Quality Control and Quality Assurance in the Mitochondrion

    296 . Protein Quality Control in Peroxisomes: Ubiquitination of the Peroxisomal Targeting Signal Receptors

    297 . Mitochondrial Dynamics: Fusion and Division

    298 . The SREBP Pathway: Gene Regulation through Sterol Sensing and Gated Protein Trafficking

    299 . Regulating Endoplasmic Reticulum Function through the Unfolded Protein Response

    300 . Signaling Pathways from Mitochondria to the Cytoplasm and Nucleus

    301 . Apoptosis Signaling: A Means to an End

    302 . Regulation of Cell Cycle Progression

    303 . Signaling During Organelle Division and Inheritance: Peroxisomes

    304 . Signaling at the Nuclear Envelope

    305 . Bidirectional Crosstalk between Actin Dynamics and Endocytosis

    306 . Signaling in Autophagy Related Pathways

    Cell -Cell and Cell-Matrix Interaction

    307 . Overview of Cell - Cell and Cell - Matrix Interactions

    308 . Interactive Signaling Pathways in the Vasculature

    309 . Signaling Pathways Involved in Cardiogenesis

    310 . Regulatory Signaling in Pancreatic Organogenesis: Implications for Aberrant Signaling in Pancreatic Cancer

    311 . Trophic Effects of Gut Hormones in the Gastrointestinal Tract

    312 . The Neurotrophin Factors

    313 . Cell to Cell and Cell-Matrix Interactions in Bone

    314 . Cell-Cell Signaling in the Testis and Ovary

    315 . Signal Transduction in T Lymphocytes

    316 . Signal Transduction via the B Cell Antigen Receptor: A Crucial Regulator of B Cell Biology

    317 . Signaling Pathways in the Normal and Neoplastic Breast

    318 . Kidney

    319 . Cytokines and Cytokine Receptors Regulating Cell Survival, Proliferation, and Differentiation in Hematopoiesis

    320 . Signaling Pathways Regulating Growth and Differentiation of Adult Stem Cells

    321 . In Vivo Imaging of Cellular Network Signaling

    DISEASE PATHOPHYSIOLOGY: Translational Implications

    322 . The Roles of Ras Family Small GTPases in Breast Cancer

    323 . Translational Implications of Stromal-Epithelial Interactions in Prostate Cancer and the Potential Role of Prostate Cancer Stem/Progenitor Cells

    324 . Aberrant Signaling Pathways in Pancreatic Cancer: Opportunities for Targeted Therapeutics

    325 . The Evolution and Maintenance of the Multiple Myeloma Cell Clone within the Liquid Bone Marrow Compartment: Therapeutic Implications

    326 . The Pathophysiologic Role of the Bone Marrow Environment and its Niches in Multiple Myeloma

    327 . Signaling Targets in Myeloid Leukemias

    328 . Signaling Targets in Lymphoid Leukemias

    329 . Targeting Ras for Anticancer Drug Discovery

    330 . Targeting EWS/FLI1 Driven Signaling Pathways as Therapy for Tumors of the Ewing’s Sarcoma Family

    331 . IRS-Protein Scaffolds and Insulin/IGF Action in Central and Peripheral Tissues

    332 . Adipokine Signaling: Implications for Obesity

    333 . Angiogenesis Signaling Pathways as Targets in Cancer Therapy

    334 . CXC Chemokine Signaling in Interstitial Lung Diseases

    335 . Systemic Sclerosis

    336 . Signal Transduction in Rheumatoid Arthritis and Systemic Lupus Erythematosus

    337 . Translational Concepts in Vasculitis

    338 . Advances in Understanding the Pathogenesis of Infl ammatory Bowel Disease

    339 . Translational Implications of Proteomics

    340 . Translational Implications of microRNAs in Clinical Diagnostics and Therapeutics


advert image